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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Diabetologia. 2013 Mar 19;56(6):1444–1453. doi: 10.1007/s00125-013-2884-2

Fig. 7.

Fig. 7

ROS is a key mediator of LPA resistance that was induced by PDR vitreous, and which could be overcome pharmacologically by targeting the RSE pathway. (a) Exogenous LPA was added to BREC tubes in the presence of hydrogen peroxide. As expected, LPA induced significant tube regression (*p<0.05). In contrast, ROS significantly inhibited regression in response to LPA (†p<0.05 vs LPA-treated tubes). (b,c) As in Fig. 6, except with the indicated additions. LPA (1 µmol/l), NAC (10 mmol/l), Su6656 (10 µmol/l) and U0126 (10 µmol/l) were added either alone or in combination with the same PDR vitreous. Inhibitors of the RSE pathway enabled LPA to promote regression in the presence of LPA vitreous. The data are means±SEM (n=4). Normalised tube length is the ratio of final and initial tube lengths. *p<0.05 vs control group.