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Demethylase activity assay of JMJD2A (top) and JMJD2C (bottom) in the presence of varying concentrations of Ni(II) ions done by immunoblotting. The lack of any band in the absence of Ni(II) ions indicates the demethylation of all the H3K9Me3. The appearance of bands in the presence of Ni(II) ions indicates that H3K9Me3 remains present due to the inhibition of the enzymes.
