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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Hypertension. 2013 Jan 21;61(3):593–601. doi: 10.1161/HYPERTENSIONAHA.111.00514

Figure 6.

Figure 6

HO-3867 inhibits vascular remodeling by restoration of phosphatase-and-tensin homolog on chromosome 10 (PTEN) activity in left-heart failure (LHF)-mediated pulmonary hypertension (PH). A, Representative images of H&E staining of lung sections show extensive muscularization of the capillary vessel walls in the LHF group indicative of vascular remodeling in comparison with the control group. The images also show a decrease in vascular remodeling on treatment with HO-3867. The results demonstrate the ability of HO-3867 in decreasing the luminal narrowing and vascular smooth muscle cell hyperplasia associated with LHF-PH. B, Western blot assays were performed on lung tissues collected after 4 weeks of left anterior descending artery ligation. Representative Western blot images and densitometric analysis of total and phosphorylated form of PTEN and Akt, normalized with respect to loading control (Actin), are shown. The data represent mean±SD; n=5; *P<0.05 versus Control; #P<0.05 versus LHF. The results show a significant downregulation of antiproliferative signaling molecule pPTEN and upregulation of prosurvival protein pAkt in the LHF group which is mitigated by HO-3867.