Table 5.
Demographic and Health Risk Profiles in Surgical vs Natural Menopause According to HT Use
| Natural Menopause | Surgical Menopause | p(HT) | p(MP) | |||||
|---|---|---|---|---|---|---|---|---|
| HT≤55 yrs HT>55 yrs No HT | HT≤55 yrs HT>55 yrs No HT | |||||||
| (n=218) | (n=62) | (n=234) | (n=97) | (n=8) | (n=28) | |||
| Age (±SD)(yrs) | 59(8) | 66(5) | 66(9) | 57(10) | 65(7) | 60(12) | <.0001 | 0.001 |
| Income ≥35K (%) | 44 | 34 | 29 | 43 | 38 | 35 | 0.02 | 0.98 |
| High School+ Ed. (%) | 84 | 71 | 73 | 81 | 75 | 78 | 0.03 | 0.84 |
| Non-White Race (%) | 16 | 23 | 18 | 16 | 25 | 11 | 0.27 | 0.56 |
| Hx Diabetes (%) | 19 | 29 | 34 | 27 | 0 | 18 | 0.10 | 0.94 |
| Chronic Disease (%) | 39 | 55 | 52 | 42 | 0 | 56 | 0.11 | 0.92 |
| Current Smoke (%) | 16 | 13 | 18 | 26 | 12 | 32 | 0.005 | 0.07 |
| BMI (±SD) | 29(6) | 29(6) | 30(6) | 30(8) | 29(6) | 31(6) | 0.03 | 0.26 |
| Metabolic Synd (%) | 23 | 31 | 32 | 28 | 12 | 48 | 0.02 | 0.36 |
| ATP III Risk (±SD) | 4(4) | 5(4) | 7(6) | 4(4) | 4(2) | 6(7) | 0.0006 | 0.06 |
| DASI (±SD) | 20(15) | 22(15) | 18(12) | 19(16) | 26(10) | 14(14) | 0.15 | 0.17 |
| Hx Depression (%) | 33 | 18 | 12 | 34 | 25 | 36 | 0.04 | 0.22 |
| Hx Cancer (%) | 12 | 10 | 17 | 14 | 0 | 32 | 0.03 | 0.22 |
| Antidepressants (%) | 26 | 18 | 10 | 24 | 0 | 18 | 0.004 | 0.65 |
| Vitamins C, E, A (%) | 32 | 35 | 26 | 28 | 38 | 11 | 0.02 | 0.29 |
| Aspirin Use (%) | 58 | 68 | 71 | 61 | 100 | 71 | 0.15 | 0.17 |
| Age at menopause | 45(8) | 49(5) | 47(6) | 39(8) | 35(8) | 35(9) | 0.008 | <.0001 |
| Years since menopause | 14(10) | 17(7) | 19(10) | 19(9) | 30(7) | 25(11) | <.0001 | <.0001 |
| Yrs since initiating HT | 16(11) | 4(4) | - | 17(10) | 3(2) | - | <.0001 | 0.44 |
| Duration of HT use | 12(10) | 3(4) | - | 12(10) | 2(1) | - | <.0001 | 0.99 |
p(HT)=p values for HT group across the entire sample after adjusting for natural vs. surgical menopause and age. p(MP)=p value for type of menopause from the same model, after adjusting for HT group and age.
BMI=body mass index, DASI=Duke Activity Status Inventory, a measure of functional capacity and physical activity habits, Hx=history of, ATP III Risk=National Cholesterol Education Program, Adult Treatment Panel III Global Coronary Heart Disease Risk Score (see Methods), Chronic Disease includes diabetes, COPD, renal disease, autoimmune disease, anorexia, or >25 drinks/week.
Non-significant variables included: marital status, Hx hypertension, Hx dyslipidemia, Hx smoking, Family Hx CAD, systolic and diastolic blood pressure, waist circumference, waist/hip ratio, prior CAD, lipid lowering therapy, antihypertensive therapy, anxiolytics, ACE inhibitors and nitrates. There were significant menopause type * HT group interaction terms for diabetes (p=0.01), Vitamins C, E, A (p=0.04), other chronic disease (p=0.01), age at menopause (p<0.0001), years since menopause (p=0.04). All other interactions were non-significant.