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Zero-powered COC immunoassay chip with patterned micropillars for covalent antibody attachment. The COC surface is oxidized in oxygen plasma and silanized with APTES. The resultant amino terminated surface is subsequently functionalized with a dextran matrix. Finally, antibody is immobilized via Schiff's base coupling to the dextran matrix. Adapted from C. Jönsson et al., Lab Chip 8, 1191 (2008) with permission from The Royal Society of Chemistry.
