Table 2. Summary of treatment toxicity.
| Toxicity Cohort1 | Grade 2 | Grade 3 | Grade 4 | |||
|---|---|---|---|---|---|---|
| A | B | A | B | A | B | |
|
| ||||||
| Anemia | 2 (6) | 1 (3) | 1 (3) | |||
| Anorexia | 2 (6) | 2 (6) | ||||
| Creatinine increase | 1 (3) | |||||
| Diarrhea | 5 (16) | 3 (9) | 1 (3) | 1 (3) | 1 (3) | |
| Edema | 2 (6) | |||||
| Fatigue | 12 (38) | 13 (41) | 1 (3) | |||
| Infection | 4 (12) | 3 (9) | 1 (3) | |||
| Mucositis | 1 (3) | |||||
| Nausea | 10 (31) | 5 (16) | 1 (3) | 1 (3) | ||
| Neutropenia | 2 (6) | 2 (6) | 3 (9) | 1 (3) | 1 (3) | |
| Rash | 5 (16) | 2 (6) | ||||
| Thrombocytopenia | 2 (6) | |||||
| Transaminase elevation | 1 (3) | |||||
| Weight loss | 1 (3) | |||||
*
numbers in parentheses indicate percentage of treated patients
1
A: astrocytoma cohort; B: oligodendroglioma cohort