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. 1967 Oct;1(5):876–882. doi: 10.1128/jvi.1.5.876-882.1967

Characterization of the Strain of Adenovirus Type 7 Carrying the Defective Monkey Cell-adapting Component

Janet S Butel 1
PMCID: PMC375364  PMID: 4316236

Abstract

The strain of adenovirus type 7 carrying the defective monkey cell-adapting component (MAC) has been further characterized. MAC is more sensitive to inactivation by ultraviolet light than the associated adenovirus, which, in turn, is more rapidly inactivated than complete simian virus 40 (SV40). The 37% dose was 16 sec for MAC, 60 sec for adenovirus, and 84 sec for SV40. Filtration through membranes revealed that both MAC and adenovirus were retained by 100-mμ filters. MAC equilibrated in cesium chloride at the same buoyant density as the complete adenovirions (1.34 g/ml). Deoxyribonucleic acid extracted from green monkey kidney cells infected with MAC-adenovirus 7 did not hybridize in vitro with SV40 complementary ribonucleic acid. The two components (MAC and adenovirus) of the virus population possess such similar biophysical properties that their separation has not yet been achieved. Evidence to date indicates that MAC is probably not derived from SV40.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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