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. 1967 Dec;1(6):1150–1157. doi: 10.1128/jvi.1.6.1150-1157.1967

Transient Inhibition of Avian Myeloblastosis Virus Reproduction by Amethopterin and Fluorodeoxyuridine

A G Knudson Jr a,1, Anna M Brodetsky a,2, M A Baluda a,3
PMCID: PMC375403  PMID: 4316249

Abstract

Avian myeloblastosis virus cannot initiate its reproduction in the presence of amethopterin or fluorodeoxyuridine. This inhibition is reversed by thymidine. Addition of either inhibitor after virus production has started does not inhibit further virus synthesis. In presence of either inhibitor, deoxyribonucleic acid synthesis is inhibited by over 90%, but ribonucleic acid synthesis is not affected. Cells resume their normal growth rate 24 hr after removal of either inhibitor.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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