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. 1968 Nov;2(11):1326–1338. doi: 10.1128/jvi.2.11.1326-1338.1968

Cytoplasmic Structures Associated with an Arbovirus Infection: Loci of Viral Ribonucleic Acid Synthesis

Philip M Grimley 1, Irene K Berezesky 1, Robert M Friedman 1
PMCID: PMC375472  PMID: 5750316

Abstract

Unique cytoplasmic structures, herein designated as type I cytopathic vacuoles (CPV-I), are found in chick embryo cells early in the logarithmic phase of Semliki Forest virus replication. High resolution autoradiography demonstrated that the CPV-I are loci of 3H-uridine incorporation. This evidence correlates well with previous biochemical data and electron microscopy of the subcellular fractions active in Semliki Forest virus ribonucleic acid synthesis. Origin of the CPV-I within host cell cytoplasm is confirmed by the distribution of electron-dense tracer particles and sequential ultrastructural observations.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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