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. 1967 Feb;1(1):193–204. doi: 10.1128/jvi.1.1.193-204.1967

Induced Structural Defects in T-Even Bacteriophage

Donald J Cummings 1, V A Chapman 1, S S De Long 1, L Mondale 1
PMCID: PMC375519  PMID: 5623954

Abstract

Multiple aberrant substructures of T-even bacteriophage particles occurred when amino acid analogues or antimetabolites were present during phage growth. Certain aberrant substructures were induced by specific analogues or antimetabolites. In particular, it was observed by electron microscopy that l-canavanine, an arginine analogue, gave rise to polyheads; l-azetidine-2-carboxylic acid, a proline analogue, gave rise to polytail tubes; and 1,2,4-trizaole-3-alanine, a histidine analogue, proflavine, and actinomycin D all gave rise to small heads. These aberrant substructures were similar to those reported earlier with conditional lethal mutants (amber) of T4D in a restrictive host.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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