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. 1968 May;2(5):488–493. doi: 10.1128/jvi.2.5.488-493.1968

Hybrid of Monkey and Human Adenoviruses

A D Altstein 1, N N Dodonova 1, N N Vassilyeva 1, E M Tsetlin 1
PMCID: PMC375638  PMID: 4301315

Abstract

Following joint replication of monkey SA7 adenovirus (C8 strain) and human adenovirus type 2 in green monkey kidney tissue culture, a virus possessing the properties of a hybrid was obtained. It was designated Ad2C8. Ad2C8 preparations contained two types of viral particles: human adenovirus type 2, and hybrid particles. The hybrid virions multiplied in green monkey kidney cells in the presence of human adenovirus types 1, 2, and 3, but not 3 and 7, and acquired the capsid of the helper adenovirus. The hybrid can serve as a helper for human adenoviruses. It can apparently induce T antigen of the C8 virus but, in contrast to the latter, does not induce tumors in hamsters.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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