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. 1969 Feb;3(2):99–105. doi: 10.1128/jvi.3.2.99-105.1969

Interferon and Host Resistance to Rauscher Virus-induced Leukemia 1

Lowell A Glasgow 1,2, Stanford B Friedman 1,2
PMCID: PMC375737  PMID: 5774143

Abstract

A random bred strain of mice (CD-1) was shown to develop resistance to Rauscher leukemia virus (RLV) as the animals matured. Resistant adult mice developed relatively high-serum levels of interferon (150 to 2,000 units per ml) in contrast to susceptible 21-day-old animals in which interferon levels were undetectable or low (less than 20 to 200 units per ml). A similar correlation between resistance and interferon levels was observed in comparisons between resistant CD-1 and susceptible BALB/c mice. The F1 hybrids of CD-1 × BALB/c and BALB/c × CD-1 matings manifested an intermediate degree of susceptibility and interferon production. The difference in interferon production by CD-1 and BALB/c mice was specific for the RLV-host interaction, since both strains produced equal serum levels of interferon in response to Sindbis and Newcastle disease viruses. The mortality of CD-1 suckling mice infected with Rauscher leukemia virus was decreased by treatment with interferon. These data demonstrate an association between interferon production by the host and the observed relative resistance of the CD-1 strain of adult mice to the subsequent malignant transformation. This virus-host relationship provides an excellent model for further study of factors affecting the development of virus-induced leukemia.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ATANASIU P., CHANY C. [Effect of interferon originating in malignant cells on experimental infection of the newborn hamster with polyoma virus]. C R Seances Soc Biol Fil. 1960 Oct 17;25:1687–1689. [PubMed] [Google Scholar]
  2. BADER J. P. Production of interferon by chick embryo cells exposed to Rous sarcoma virus. Virology. 1962 Apr;16:436–443. doi: 10.1016/0042-6822(62)90224-6. [DOI] [PubMed] [Google Scholar]
  3. Boiron M., Levy J. P., Lasneret J., Oppenheim S., Bernard J. Pathogenesis of Rauscher leukemia. J Natl Cancer Inst. 1965 Nov;35(5):865–884. [PubMed] [Google Scholar]
  4. FRIEDMAN R. M., RABSON A. S. POSSIBLE ROLE OF INTERFERON IN DETERMINING THE ONCOGENIC EFFECT OF POLYOMA VIRUS VARIANTS. J Exp Med. 1964 Jan 1;119:71–81. doi: 10.1084/jem.119.1.71. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. GLASGOW L. A. INTERFERON: A REVIEW. J Pediatr. 1965 Jul;67:104–112. doi: 10.1016/s0022-3476(65)80311-0. [DOI] [PubMed] [Google Scholar]
  6. GLASGOW L. A. LEUKOCYTES AND INTERFERON IN THE HOST RESPONSE TO VIRAL INFECTIONS. I. MOUSE LEUKOCYTES AND LEUKOCYTE-PRODUCED INTERFERON IN VACCINIA VIRUS INFECTION IN VITRO. J Exp Med. 1965 Jun 1;121:1001–1018. doi: 10.1084/jem.121.6.1001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gresser I., Coppey J., Fontaine-Brouty-Boye D., Falcoff R., Falcoff E., Zajdela F. Interferon and murine leukaemia. 3. Efficacy of interferon preparations administered after inoculation of Friend virus. Nature. 1967 Jul 8;215(5097):174–175. doi: 10.1038/215174a0. [DOI] [PubMed] [Google Scholar]
  8. Gresser I., Fontaine D., Coppey J., Falcoff R., Falcoff E. Interferon and murine leukemia. II. Factors related to the inhibitory effect of interferon preparations on development of Friend leukemia in mice. Proc Soc Exp Biol Med. 1967 Jan;124(1):91–94. doi: 10.3181/00379727-124-31673. [DOI] [PubMed] [Google Scholar]
  9. LAMPSON G. P., TYTELL A. A., NEMES M. M., HILLEMAN M. R. Purification and characterization of chick embryo interferon. Proc Soc Exp Biol Med. 1963 Feb;112:468–478. doi: 10.3181/00379727-112-28080. [DOI] [PubMed] [Google Scholar]
  10. Peries J., Boiron M., Canivet M. Recherche d'une production d'interféron et d'une interférence virale hétérologue dans une lignée cellulaire chroniquement infectée par le virus de Rauscher. Ann Inst Pasteur (Paris) 1965 Oct;109(4):595–600. [PubMed] [Google Scholar]
  11. RAUSCHER F. J. A virus-induced disease of mice characterized by erythrocytopoiesis and lymphoid leukemia. J Natl Cancer Inst. 1962 Sep;29:515–543. [PubMed] [Google Scholar]
  12. STRANDSTROM H., SANDELIN K., OKER-BLOM N. Inhibitory effect of Coxsackie virus, influenza virus, and interferon on Rous Sarcoma virus. Virology. 1962 Apr;16:384–391. doi: 10.1016/0042-6822(62)90217-9. [DOI] [PubMed] [Google Scholar]
  13. Todaro G. J., Baron S. The role of interferon in the inhibition of SV40 transformation of mouse cell line 3T3. Proc Natl Acad Sci U S A. 1965 Sep;54(3):752–756. doi: 10.1073/pnas.54.3.752. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Wheelock E. F., Larke R. P. Efficacy of interferon in the treatment of mice with established Friend virus leukemia. Proc Soc Exp Biol Med. 1968 Jan;127(1):230–238. doi: 10.3181/00379727-127-32663. [DOI] [PubMed] [Google Scholar]

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