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. 1969 Sep;4(3):197–202. doi: 10.1128/jvi.4.3.197-202.1969

Replication of Canine Herpesvirus

I. Synthesis of Viral Deoxyribonucleic Acid

Laure Aurelian 1
PMCID: PMC375857  PMID: 16789092

Abstract

This paper reports the results of two series of experiments. The first series indicated that deoxyribonucleic acid (DNA) extracted from partially purified canine herpesvirus virions is characterized by a high guanine plus cytosine molar base ratio (65 to 67 mole%), similar to the DNA of herpes simplex virus. In the second series of experiments it was estimated, on the basis of uptake of tritiated thymidine, that in dog kidney cells canine herpesvirus-DNA synthesis starts at 4 hr and continues until 16 hr after infection. Treatment of infected cells with puromycin during the first 4 hr of infection blocks the onset of viral DNA synthesis, whereas, after this time the uptake of thymidine is unaffected.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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