Sir,
Kumar et al.[1] commented our systematic review[2] on a large scale meta-analysis of genetic studies in ischemic stroke.
Casas et al.[3,4] made 2 different studies with different sample size (3,387 cases, 4,597 controls and 6,324 cases, 7,604 controls), the 2 works are reported in Bersano et al.[5] which had normally increased the sample size.
We followed the same criteria for selection of studies for the five genes polymorphisms (Prothrombin, Factor V Leiden, Angiotensin Converting Enzyme, Methylenetetrahydrofolate Reductase and Apolipoproteine E gene meta-analysis since we selected works with the pooling of 5 genes in same ethnic population with strict criteria.
References
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