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. 1969 Oct;4(4):490–495. doi: 10.1128/jvi.4.4.490-495.1969

Mengovirus-Induced Cytopathic Effect in L-Cells: Protective Effect of Interferon

A T Haase 1, S Baron 1, H Levy 1, J A Kasel 1
PMCID: PMC375898  PMID: 4309883

Abstract

The effect of interferon on mengovirus-induced cytopathic effect (CPE) in L cells, the cut-off of host-cell protein synthesis, and production of mature virus were found to be dependent on the concentration of interferon. CPE and inhibition of host protein synthesis were not affected until the concentration of interferon was increased 100-fold over that required to reduce viral yields by 90%.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALLISON A. C., MALLUCCI L. HISTOCHEMICAL STUDIES OF LYSOSOMES AND LYSOSOMAL ENZYMES IN VIRUS-INFECTED CELL CULTURES. J Exp Med. 1965 Mar 1;121:463–476. doi: 10.1084/jem.121.3.463. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Amako K., Dales S. Cytopathology of Mengovirus infection. I. Relationship between cellular disintegration and virulence. Virology. 1967 Jun;32(2):184–200. doi: 10.1016/0042-6822(67)90269-3. [DOI] [PubMed] [Google Scholar]
  3. BABLANIAN R., EGGERS H. J., TAMM I. STUDIES ON THE MECHANISM OF POLIOVIRUS-INDUCED CELL DAMAGE. I. THE RELATION BETWEEN POLIOVIRUS,-INDUCED METABOLIC AND MORPHOLOGICAL ALTERATIONS IN CULTURED CELLS. Virology. 1965 May;26:100–113. doi: 10.1016/0042-6822(65)90030-9. [DOI] [PubMed] [Google Scholar]
  4. BALTIMORE D., FRANKLIN R. M., CALLENDER J. MENGOVIRUS-INDUCED INHIBITION OF HOST RIBONUCLEIC ACID AND PROTEIN SYNTHESIS. Biochim Biophys Acta. 1963 Nov 22;76:425–430. [PubMed] [Google Scholar]
  5. BARON S., BUCKLER C. E. CIRCULATING INTERFERON IN MICE AFTER INTRAVENOUS INJECTION OF VIRUS. Science. 1963 Sep 13;141(3585):1061–1063. doi: 10.1126/science.141.3585.1061. [DOI] [PubMed] [Google Scholar]
  6. Bablanian R. The prevention of early vaccinia-virus-induced cytopathic effects by inhibition of protein synthesis. J Gen Virol. 1968 Jul;3(1):51–61. doi: 10.1099/0022-1317-3-1-51. [DOI] [PubMed] [Google Scholar]
  7. Baron S., Buckler C. E., Levy H. B., Friedman R. M. Some factors affecting the interferon-induced antiviral state. Proc Soc Exp Biol Med. 1967 Aug-Sep;125(4):1320–1326. doi: 10.3181/00379727-125-32347. [DOI] [PubMed] [Google Scholar]
  8. ENNIS H. L., LUBIN M. CYCLOHEXIMIDE: ASPECTS OF INHIBITION OF PROTEIN SYNTHESIS IN MAMMALIAN CELLS. Science. 1964 Dec 11;146(3650):1474–1476. doi: 10.1126/science.146.3650.1474. [DOI] [PubMed] [Google Scholar]
  9. Gauntt C. J., Lockart R. Z., Jr Destruction of L cells by Mengo virus: use of interferon to study the mechanism. J Virol. 1968 Jun;2(6):567–575. doi: 10.1128/jvi.2.6.567-575.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Gauntt C. J., Lockart R. Z., Jr Inhibition of Mengo virus by interferon. J Bacteriol. 1966 Jan;91(1):176–182. doi: 10.1128/jb.91.1.176-182.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Joklik W. K., Merigan T. C. Concerning the mechanism of action of interferon. Proc Natl Acad Sci U S A. 1966 Aug;56(2):558–565. doi: 10.1073/pnas.56.2.558. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. LEVY H. B. STUDIES ON THE MECHANISM OF INTERFERON ACTION. II. THE EFFECT OF INTERFERON ON SOME EARLY EVENTS IN MENGO VIRUS INFECTION IN L CELLS. Virology. 1964 Apr;22:575–579. doi: 10.1016/0042-6822(64)90079-0. [DOI] [PubMed] [Google Scholar]
  13. LIEBHABER H., TAKEMOTO K. K. Alteration plaque morphology of EMC virus with polycations. Virology. 1961 Aug;14:502–504. doi: 10.1016/0042-6822(61)90349-x. [DOI] [PubMed] [Google Scholar]
  14. Levy H. B., Carter W. A. Molecular basis of the action of interferon. J Mol Biol. 1968 Feb 14;31(3):561–577. doi: 10.1016/0022-2836(68)90428-2. [DOI] [PubMed] [Google Scholar]
  15. Marcus P. I., Salb J. M. Molecular basis of interferon action: inhibition of viral RNA translation. Virology. 1966 Nov;30(3):502–516. doi: 10.1016/0042-6822(66)90126-7. [DOI] [PubMed] [Google Scholar]
  16. Moss B. Inhibition of HeLa cell protein synthesis by the vaccinia virion. J Virol. 1968 Oct;2(10):1028–1037. doi: 10.1128/jvi.2.10.1028-1037.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]

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