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. 1969 Oct;4(4):545–546. doi: 10.1128/jvi.4.4.545-546.1969

Factors Influencing Virulence and Plaque Properties of Attenuated Venezuelan Equine Encephalomyelitis Virus Populations

Henry J Hearn 1, Zenonas V Seliokas 1,1, Arthur A Andersen 1,2
PMCID: PMC375906  PMID: 5823235

Abstract

A minority of stable large-plaque virus increased proportionally in stored unstable attenuated (9t) Venezuelan equine encephalomyelitis virus populations. L-cell-grown progeny (9t2) of stored 9t showed large amounts of large-plaque virus and increased virulence. Small-plaque virus inhibited large-plaque virus but not the reverse. Serial passage of small-plaque virus from 9t2 yielded a strain (20t) that was more attenuated than 9t.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Hearn H. J., Jr, Soper W. T. Properties of Venezuelan equine encephalomyelitis virus accompanying attenuation in vitro. J Virol. 1967 Jun;1(3):453–459. doi: 10.1128/jvi.1.3.453-459.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]

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