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. 1969 Nov;4(5):753–762. doi: 10.1128/jvi.4.5.753-762.1969

Morphogenesis of Newcastle Disease Virus in Chorioallantoic Membrane

Ursula Feller 1, Robert M Dougherty 1, Henry S Di Stefano 1
PMCID: PMC375934  PMID: 5391161

Abstract

Chick embryo chorioallantoic membrane, infected with the Blacksburg strain of Newcastle disease virus, was examined with an electron microscope to investigate the sequence of viral-induced host cell alterations. These were evident mostly in the endodermal epithelial cells lining the allantoic sac and were divided arbitrarily into three stages. Stage 1 was characterized by commencement of cell hypertrophy and hyperplasia and presence of fewer cytoplasmic inclusion bodies normally found in the cells; in stage 2, juxtanuclear nucleocapsid-glycogen aggregates appeared, and there were increased numbers of microvilli; stage 3 was characterized by increased cytoplasmic density and evidence of viral assembly and release. The morphological features of viral assembly and the virion are also described.

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These references are in PubMed. This may not be the complete list of references from this article.

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