Abstract
The development of the virus of bovine ephemeral fever in mouse brain has been studied by electron microscopy. The virus particles are bullet-shaped, 70 by 145 nm, and slightly tapered toward the rounded end. The outer envelope is closely apposed to an electron-dense shell, about 12 nm thick, but no other internal structure is visible. The virus strains studied bud from the marginal membranes of neurones, but intracytoplasmic development, possibly aberrant, was also observed with one strain. Ephemeral fever virus is thus obviously a rhabdovirus, with points of resemblance to vesicular stomatitis, Flanders-Hart Park, and Kern Canyon viruses on the one hand, and to rabies virus on the other, but is structurally distinct from any of these.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- David-West T. S., Labzoffsky N. A. Electron microscopic studies on the development of vesicular stomatitis virus. Arch Gesamte Virusforsch. 1968;23(1):105–125. doi: 10.1007/BF01242119. [DOI] [PubMed] [Google Scholar]
- Dierks R. E., Murphy F. A., Harrison A. K. Extraneural rabies virus infection. Virus development in fox salivary gland. Am J Pathol. 1969 Feb;54(2):251–273. [PMC free article] [PubMed] [Google Scholar]
- Huang A. S., Greenawalt J. W., Wagner R. R. Defective T particles of vesicular stomatitis virus. I. Preparation, morphology, and some biologic properties. Virology. 1966 Oct;30(2):161–172. doi: 10.1016/0042-6822(66)90092-4. [DOI] [PubMed] [Google Scholar]
- Inaba Y., Tanaka Y., Sato K., Ito H., Omori T. Propagation in laboratory animals and cell cultures of a virus from cattle with bovine epizootic fever. Jpn J Microbiol. 1968 Jun;12(2):253–255. doi: 10.1111/j.1348-0421.1968.tb00392.x. [DOI] [PubMed] [Google Scholar]
- Ito Y., Tanaka Y., Inaba Y., Omori T. Electron microscopic observations of bovine epizootic fever virus. Natl Inst Anim Health Q (Tokyo) 1969 Spring;9(1):35–44. [PubMed] [Google Scholar]
- Murphy F. A., Coleman P. H., Whitfield S. G. Electron microscopic observations of Flanders virus. Virology. 1966 Oct;30(2):314–317. doi: 10.1016/0042-6822(66)90107-3. [DOI] [PubMed] [Google Scholar]
- Nakai T., Howatson A. F. The fine structure of vesicular stomatitis virus. Virology. 1968 Jun;35(2):268–281. doi: 10.1016/0042-6822(68)90267-5. [DOI] [PubMed] [Google Scholar]
- Sasaki N., Kodama K., Iwamoto I., Izumida A., Matsubara T. Serial transmission in suckling mice of a virus from cattle with bovine epizootic fever. Jpn J Microbiol. 1968 Jun;12(2):251–252. doi: 10.1111/j.1348-0421.1968.tb00391.x. [DOI] [PubMed] [Google Scholar]
- VENABLE J. H., COGGESHALL R. A SIMPLIFIED LEAD CITRATE STAIN FOR USE IN ELECTRON MICROSCOPY. J Cell Biol. 1965 May;25:407–408. doi: 10.1083/jcb.25.2.407. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wagner R. R., Schnaitman T. C., Snyder R. M., Schnaitman C. A. Protein composition of the structural components of vesicular stomatitis virus. J Virol. 1969 Jun;3(6):611–618. doi: 10.1128/jvi.3.6.611-618.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
- van der Westhuizen B. Studies on bovine ephemeral fever. I. Isolation and preliminary characterization of a virus from natural and experimentally produced cases of bovine ephemeral fever. Onderstepoort J Vet Res. 1967 Apr;34(1):29–40. [PubMed] [Google Scholar]