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. 1970 Feb;5(2):221–225. doi: 10.1128/jvi.5.2.221-225.1970

Host-Range Restrictions of Murine Leukemia Viruses in Mouse Embryo Cell Cultures

Janet W Hartley 1, Wallace P Rowe 1, Robert J Huebner 1
PMCID: PMC375990  PMID: 4317349

Abstract

Murine leukemia virus strains fall into three categories with respect to their ability to propagate in cells of National Institutes of Health (NIH) Swiss and BALB/c mouse embryos. Cultures of NIH cells are 100- to 1,000-fold more sensitive to “N-tropic” strains than BALB/c cell cultures, but are 30- to 100-fold less sensitive to “B-tropic” strains. Some virus strains (dually tropic or “NB-tropic”) propagate equally well in both cells. M-MSV pseudotypes show the host-range characteristics of the virus supplying the envelope, both in vitro and in vivo. The host-range characteristics appear to be genetically determined and could not be explained by host-induced modification or virus mixtures. There was no correlation between host range and Gross-AKR or FMR serotype.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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