Abstract
Intraperitoneal injection of chlorite-oxidized oxyamylose (COAM) protected mice against mengo, vaccinia, Semliki Forest, and influenza APR8 viruses. Topical administration in the eye of rabbits partially inhibited the development of experimental herpetic keratoconjunctivitis. COAM resembled polyacrylic acid in many aspects, but it was markedly less toxic. For systemic administration, the therapeutic index was on the order of magnitude of 1:300 to 1:500. Although the in vivo antiviral effect of COAM wore off faster than that of polyacrylic acid, protection lasted for several weeks. Against mengovirus, such prolonged protection was achieved only when polymer and virus were injected intraperitoneally. Protection against intravenous vaccinia virus was not dependent on the injection route of COAM. Experiments on the mode of action of COAM pointed to macrophages as possible mediators of the antiviral effect. The fact that small amounts of interferon appeared in the serum after administration of high doses of COAM suggests that interferon may play a role in the induction of antiviral resistance by COAM.
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Selected References
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- Boyle J. J., Haff R. F., Stewart R. C. Evaluation of antiviral compounds by suppression of tail lesions in vaccinia-infected mice. Antimicrob Agents Chemother (Bethesda) 1966;6:536–539. [PubMed] [Google Scholar]
- Claes P., Billiau A., De Clercq E., Desmyter J., Schonne E., Vanderhaeghe H., De Somer P. Polyacetal carboxylic acids: a new group of antiviral polyanions. J Virol. 1970 Mar;5(3):313–320. doi: 10.1128/jvi.5.3.313-320.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
- De Clercq E., De Somer P. Effect of interferon, polyacrylin acid, and polymethacrylic acid on tail lesions on mice infected with vaccinia virus. Appl Microbiol. 1968 Sep;16(9):1314–1319. doi: 10.1128/am.16.9.1314-1319.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- De Clercq E., De Somer P. Protective effect of interferon and polyacrylic acid in newborn mice infected with a lethal dose of vesicular stomatitis virus. Life Sci. 1968 Sep 1;7(17):925–933. doi: 10.1016/0024-3205(68)90098-2. [DOI] [PubMed] [Google Scholar]
- De Somer P., Billiau A. Interferon production by the spleen of rats after intravenous injection of Sindbis virus or heat-killed Escherichia coli. Arch Gesamte Virusforsch. 1966;19(2):143–154. doi: 10.1007/BF01241494. [DOI] [PubMed] [Google Scholar]
- De Somer P., De Clercq E., Billiau A., Schonne E., Claesen M. Antiviral activity of polyacrylic and polymethacrylic acids. I. Mode of action in vitro. J Virol. 1968 Sep;2(9):878–885. doi: 10.1128/jvi.2.9.878-885.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- De Somer P., De Clercq E., Billiau A., Schonne E., Claesen M. Antiviral activity of polyacrylic and polymethacrylic acids. II. Mode of action in vivo. J Virol. 1968 Sep;2(9):886–893. doi: 10.1128/jvi.2.9.886-893.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Merigan T. C., Finkelstein M. S. Interferon-stimulating and in vivo antiviral effects of various synthetic anionic polymers. Virology. 1968 Jul;35(3):363–374. doi: 10.1016/0042-6822(68)90215-8. [DOI] [PubMed] [Google Scholar]
- Merigan T. C. Induction of circulating interferon by synthetic anionic polymers of known composition. Nature. 1967 Apr 22;214(5086):416–417. doi: 10.1038/214416a0. [DOI] [PubMed] [Google Scholar]
- Panijel J., Cayeux P. Immunosuppressive effects of macrophage antiserum. Immunology. 1968 Jun;14(6):769–780. [PMC free article] [PubMed] [Google Scholar]
- Youngner J. S., Stinebring W. R. Interferon appearance stimulated by endotoxin, bacteria, or viruses in mice pre-treated with Escherichia coli endotoxin or infected with Mycobacterium tuberculosis. Nature. 1965 Oct 30;208(5009):456–458. doi: 10.1038/208456a0. [DOI] [PubMed] [Google Scholar]