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. 2013 Feb 28;29(2):155–164. doi: 10.1007/s12264-013-1314-2

Regulation of the timing of oligodendrocyte differentiation: mechanisms and perspectives

Hao Huang 11314, Xiao-Feng Zhao 11314, Kang Zheng 11314, Mengsheng Qiu 11314,21314,✉
PMCID: PMC3761796  NIHMSID: NIHMS505744  PMID: 23456566

Abstract

Axonal myelination is an essential process for normal functioning of the vertebrate central nervous system. Proper formation of myelin sheaths around axons depends on the timely differentiation of oligodendrocytes. This differentiation occurs on a predictable schedule both in culture and during development. However, the timing mechanisms for oligodendrocyte differentiation during normal development have not been fully uncovered. Recent studies have identified a large number of regulatory factors, including cell-intrinsic factors and extracellular signals, that could control the timing of oligodendrocyte differentiation. Here we provide a mechanistic and critical review of the timing control of oligodendrocyte differentiation.

Keywords: oligodendrocytes, differentiation, timing, remyelination

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