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. 1971 Nov;8(5):656–660. doi: 10.1128/jvi.8.5.656-660.1971

Inhibition of the Synthesis of Simian Virus 40 Antigens in Cells Preinfected with Yaba Tumor Virus 1

Y Tsuchiya 1,2, H Rouhandeh 1
PMCID: PMC376243  PMID: 4332136

Abstract

The synthesis of tumor and viral antigens after infection of an established line of cynomolgus monkey kidney cells with simian virus 40 (SV40) was compared in cells previously infected with Yaba virus and in cells not preinfected. SV40 failed to induce synthesis of tumor or viral antigens in cells preinfected with Yaba virus. The inhibitory state in preinfected cells was shown to develop sequentially. Increase in the rate of deoxyribonucleic acid synthesis in the nuclei of preinfected cells occurred after infection with SV40. This rate of increase was significantly lower than that which occurred in SV40-infected cells which had not been preinfected. Cytosine arabinoside did not exert significant effect on the development of the inhibitory effect against SV40 in Yaba virus-infected cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BECKER Y., JOKLIK W. K. MESSENGER RNA IN CELLS INFECTED WITH VACCINIA VIRUS. Proc Natl Acad Sci U S A. 1964 Apr;51:577–585. doi: 10.1073/pnas.51.4.577. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Dulbecco R., Johnson T. Interferon-sensitivity of the enhanced incorporation of thymidine into cellular DNA induced by polyoma virus. Virology. 1970 Oct;42(2):368–374. doi: 10.1016/0042-6822(70)90280-1. [DOI] [PubMed] [Google Scholar]
  3. Gershon D., Hausen P., Sachs L., Winocour E. On the mechanism of polyoma virus-induced synthesis of cellular DNA. Proc Natl Acad Sci U S A. 1965 Dec;54(6):1584–1592. doi: 10.1073/pnas.54.6.1584. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gershon D., Sachs L., Winocour E. The induction of cellular DNA synthesis by simian virus 40 in contact-inhibited and in x-irradiated cells. Proc Natl Acad Sci U S A. 1966 Sep;56(3):918–925. doi: 10.1073/pnas.56.3.918. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hatanaka M., Dulbecco R. Induction of DNA synthesis by SV40. Proc Natl Acad Sci U S A. 1966 Aug;56(2):736–740. doi: 10.1073/pnas.56.2.736. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Henry P., Black P. H., Oxman M. N., Weissman S. M. Stimulation of DNA synthesis in mouse cell line 3T3 by Simian virus 40. Proc Natl Acad Sci U S A. 1966 Oct;56(4):1170–1176. doi: 10.1073/pnas.56.4.1170. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hirt B. Selective extraction of polyoma DNA from infected mouse cell cultures. J Mol Biol. 1967 Jun 14;26(2):365–369. doi: 10.1016/0022-2836(67)90307-5. [DOI] [PubMed] [Google Scholar]
  8. JOKLIK W. K. The purification fo four strains of poxvirus. Virology. 1962 Sep;18:9–18. doi: 10.1016/0042-6822(62)90172-1. [DOI] [PubMed] [Google Scholar]
  9. KATO S., TSURU K., MIYAMOTO H. AUTORADIOGRAPHIC STUDIES ON THE YABA MONKEY TUMOR VIRUS AND HOST CELL INTERACTION. Biken J. 1965 Apr;8:45–53. [PubMed] [Google Scholar]
  10. KIT S., DUBBS D. R. Biochemistry of vaccinia-infected mouse fibroblasts (strain L-M). I. Effects on nucleic acid and protein synthesis. Virology. 1962 Oct;18:274–285. doi: 10.1016/0042-6822(62)90014-4. [DOI] [PubMed] [Google Scholar]
  11. McCutchan J. H., Pagano J. S. Enchancement of the infectivity of simian virus 40 deoxyribonucleic acid with diethylaminoethyl-dextran. J Natl Cancer Inst. 1968 Aug;41(2):351–357. [PubMed] [Google Scholar]
  12. Miyamoto H., Kato S. Immune hemadsorption by cells infected with poxviruses. Biken J. 1968 Dec;11(4):343–353. [PubMed] [Google Scholar]
  13. Moss B. Inhibition of HeLa cell protein synthesis by the vaccinia virion. J Virol. 1968 Oct;2(10):1028–1037. doi: 10.1128/jvi.2.10.1028-1037.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. RAPP F., BUTEL J. S., FELDMAN L. A., KITAHARA T., MELNICK J. L. DIFFERENTIAL EFFECTS OF INHIBITORS ON THE STEPS LEADING TO THE FORMATION OF SV40 TUMOR AND VIRUS ANTIGENS. J Exp Med. 1965 Jun 1;121:935–944. doi: 10.1084/jem.121.6.935. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. SHATKIN A. J. ACTINOMYCIN D AND VACCINIA VIRUS INFECTION OF HELA CELLS. Nature. 1963 Jul 27;199:357–358. doi: 10.1038/199357a0. [DOI] [PubMed] [Google Scholar]
  16. Sauer G., Defendi V. Stimulation of DNA synthesis and complement-fixing antigen production by SV40 in human diploid cell cultures: evidence for "abortive" infection. Proc Natl Acad Sci U S A. 1966 Aug;56(2):452–457. doi: 10.1073/pnas.56.2.452. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Todaro G. J., Lazar G. K., Green H. The initiation of cell division in a contact-inhibited mammalian cell line. J Cell Physiol. 1965 Dec;66(3):325–333. doi: 10.1002/jcp.1030660310. [DOI] [PubMed] [Google Scholar]
  18. Tsuchiya Y., Tagaya I. Enhanced or inhibited plaque formation of superinfecting viruses in Yaba virus-infected cells. J Gen Virol. 1970 Apr;7(1):71–73. doi: 10.1099/0022-1317-7-1-71. [DOI] [PubMed] [Google Scholar]
  19. Tsuchiya Y., Tagaya I., Tsuruhara T. Titration and extensive serial passages of Yaba virus in vitro. Jpn J Microbiol. 1969 Mar;13(1):103–117. doi: 10.1111/j.1348-0421.1969.tb00440.x. [DOI] [PubMed] [Google Scholar]
  20. Tsuchiya Y., Takayama R., Tagaya I. Establishment of a cynomolgus monkey kidney cell line and its susceptibility to various viruses. Jpn J Med Sci Biol. 1969 Apr;22(2):101–115. doi: 10.7883/yoken1952.22.101. [DOI] [PubMed] [Google Scholar]
  21. Uchida S., Watanabe S., Kato M. Incomplete growth of simian virus 40 in African green monkey kidney culture induced by serial undiluted passages. Virology. 1966 Jan;28(1):135–141. doi: 10.1016/0042-6822(66)90314-x. [DOI] [PubMed] [Google Scholar]
  22. Ueda Y., Ito M., Tagaya I. A specific surface antigen induced by poxvirus. Virology. 1969 May;38(1):180–182. doi: 10.1016/0042-6822(69)90141-x. [DOI] [PubMed] [Google Scholar]
  23. Yohn D. S., Marmol F. R., Olsen R. G. Growth kinetics of Yaba tumor poxvirus after in vitro adaptation to cercopithecus kidney cells. J Virol. 1970 Feb;5(2):205–211. doi: 10.1128/jvi.5.2.205-211.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]

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