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. 1971 Sep;22(3):380–386. doi: 10.1128/am.22.3.380-386.1971

Dose Responsiveness and Variation Among Inbred Strains of Mice in Production of Interferon After Treatment with Poly (I)· Poly (C) [Poly-d-Lysine] Complexes

J M Rice 1,2,3, W Turner 1,2,3, M A Chirigos 1,2,3, G Spahn 1,2,3
PMCID: PMC376318  PMID: 4330315

Abstract

Poly-d-lysine forms a stochiometric complex with poly(I) · poly(C) which has a higher Tm (83 C in 0.15 m NaCl) than the uncomplexed double-stranded polyribo-nucleotide (63 C). The complex was superior to poly(I) · poly(C) alone as an interferon inducer in vivo. Significant serum interferon titers were attained in Swiss mice during a 24-hr period after intraperitoneal injection of 10 to 300 μg of poly(I) · poly(C) [1.0 poly-d-lysine] complex, at concentrations of 100 to 1,000 μg/ml. The serum interferon responses (average and maximum titers) of a series of inbred strains of mice to a single intraperitoneal injection of 100 μg of complex decreased in the order: Swiss > DBA/2 > C3H > BALB/c > CF-1 > AKR, C57Bl/6, NZB > SJL > NZW and varied by a factor of approximately 100 from the most to the least responsive.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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