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. 1971 Dec;22(6):957–962. doi: 10.1128/am.22.6.957-962.1971

Effects of Actinobolin on Growth and Some Metabolic Activities of Cariogenic Streptococci In Vitro and In Vivo

Bernard B Keele Jr 1,2,3, Hubert L Powell Jr 1,2,3, Juan M Navia 1,2,3, Jerry McGhee 1,2,3
PMCID: PMC376469  PMID: 4944810

Abstract

Actinobolin, a known inhibitor of protein synthesis, has been shown not to interfere selectively with acid production or dextransucrase activity in a cariogenic streptococcus when the antibiotic is added to a concentration of 500 μg/ml. It has also been shown that actinobolin does not alter the total in vivo flora of the oral cavity of the rat when tested in a rat caries model system. A culture of cariogenic streptococci, adapted to in vitro growth in the presence of 1 mg of actinobolin per ml, has also been isolated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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