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. 1971 Dec;22(6):987–991. doi: 10.1128/am.22.6.987-991.1971

Production of l-Arginine by Arginine Hydroxamate-Resistant Mutants of Bacillus subtilis

Masahiko Kisumi 1,2, Jyoji Kato 1,2, Masaki Sugiura 1,2, Ichiro Chibata 1,2
PMCID: PMC376473  PMID: 5002904

Abstract

l-Arginine hydroxamate inhibited the growth of various bacteria, and the inhibition was readily reversed by arginine. l-Arginine hydroxamate (10−3m) completely inhibited the growth of Bacillus subtilis. This inhibitory effect was prevented by 2.5 × 10−4ml-arginine, which was the most effective of all the natural amino acids in reversing the inhibition. l-Arginine hydroxamate-resistant mutants of Bacillus subtilis were isolated and found to excrete l-arginine in relatively high yields. One of the mutants, strain AHr-5, produced 4.5 mg of l-arginine per ml in shaken culture in 3 days.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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