Abstract
A rapid and accurate method is described for the determination of griseofulvin and dechlorogriseofulvin extracted from Penicillium urticae with chloroform. Thinlayer chromatography was used to tentatively identify griseofulvin or dechlorogriseofulvin, or both. Two gas-liquid chromatographic systems provided additional qualitative information and simultaneous quantitation of the individual compounds.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BEDFORD C., CHILD K. J., TOMICH E. G. Spectrophotofluorometric assay of griseofulvin. Nature. 1959 Aug 1;184(Suppl 6):364–365. doi: 10.1038/184364a0. [DOI] [PubMed] [Google Scholar]
- Dryon L. Contribution a l'étude analytique de quelques antifungiques utilisés en thérapeutique. J Pharm Belg. 1966 Sep-Oct;21(9):433–476. [PubMed] [Google Scholar]
- EFIMOVA G. V., MARKOVICH A. V. O SPEKTROFOTOMETRICHESKOM OPREDELENII GRIZEOFUL'VINA V MITSELII. Antibiotiki. 1964 Jul;9:592–595. [PubMed] [Google Scholar]
- EFIMOVA G. V., MARKOVICH A. V. OPREDELENIE GRIZEOFUL'VINA I 6-DEMETILGRIZEOFUL'VINA V MOCHE SPEKTROFOTOMETRICHESKIM METODOM. Vopr Med Khim. 1963 Jul-Aug;9:429–434. [PubMed] [Google Scholar]
- EISENBRANDT K. PHOTOFLUOROMETRISCHE BESTIMMUNG VON GRISEOFULVIN. Pharmazie. 1964 Jun;19:406–407. [PubMed] [Google Scholar]
- Fischer L. J., Riegelman S. Quantitative determination of griseofulvin and griseofulvin-4'-alcohol in plasma by fluorimetry on thin layer chromatograms. J Chromatogr. 1966 Feb;21(2):268–274. doi: 10.1016/s0021-9673(01)91301-9. [DOI] [PubMed] [Google Scholar]
- HOLBROOK A., BAILEY F., BAILEY G. M. A QUANTITATIVE CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF PURITY OF GRISEOFULVIN. J Pharm Pharmacol. 1963 Dec;15:SUPPL–277. doi: 10.1111/j.2042-7158.1963.tb11223.x. [DOI] [PubMed] [Google Scholar]
- HOLBROOK A., BAILEY F., BAILEY G. M. A RAPID METHOD FOR THE DETERMINATION OF GRISEOFULVIN IN FERMENTER BROTH. J Pharm Pharmacol. 1963 Dec;15:SUPPL–273. doi: 10.1111/j.2042-7158.1963.tb11222.x. [DOI] [PubMed] [Google Scholar]
- HORNING E. C., VANDENHEUVEL W. J., CREECH B. G. SEPARATION AND DETERMINATION OF STEROIDS BY GAS CHROMATOGRAPHY. Methods Biochem Anal. 1963;11:69–147. doi: 10.1002/9780470110294.ch2. [DOI] [PubMed] [Google Scholar]
- Ivanov N. M., Nevinskii A. A., Redi N. S. Fluorometricheskoe opredelenie grizeoful'vina. Lab Delo. 1965;9:564–566. [PubMed] [Google Scholar]
- Kleine-Natrop H. E., Bärwald G., Seebacher C. Vergleichende Griseofulvin-Serumspiegelbestimmungen nach Verabreichung von "Griseofulvin AWD" und "Gricin" unter Anwendung einer neuen biologischen Testmethode. Dtsch Gesundheitsw. 1965 Jul 29;20(30):1375–1383. [PubMed] [Google Scholar]
- Kraml M., Dubuc J., Dvornik D. Modification of the spectrophotofluorometric determination of griseofulvin. J Pharm Sci. 1965 Apr;54(4):655–656. doi: 10.1002/jps.2600540441. [DOI] [PubMed] [Google Scholar]
- STEPANISHCHEVA Z. G., ZISERMAN V. E. K METODIKE OPREDELENIIA GRIZEOFUL'VINA V KOZHE I VOLOSAKH. Vestn Dermatol Venerol. 1963 Sep;37:26–28. [PubMed] [Google Scholar]
- Unterman Kh V., Idel A. Iodometricheskii metod opredeleniia grizeoful'vina v fermentatsionnykh zhidkostiakh. Antibiotiki. 1968 Apr;13(4):319–323. [PubMed] [Google Scholar]
