Abstract
The absorption and retention of kanamycin by the pulmonary system was evaluated after aerosol administration to rats. Tissue level concentrations of the drug were assayed by the agar-plate bioassay method. Mean concentrations of 6.58 μg/g and 3.52 μg/g were found in the lung and kidney homogenates, respectively, 26 hr after the final exposure period. No detectable level was found in the plasma.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bilodeau M., Roy J. C., Giroux M. Studies of absorption of kanamycin by aerosolization. Ann N Y Acad Sci. 1966 Jun 14;132(2):870–878. doi: 10.1111/j.1749-6632.1966.tb43007.x. [DOI] [PubMed] [Google Scholar]
- Cohn I., Jr Kanamycin as an intestinal antiseptic and in the treatment of peritonitis: resume of clinical experience. Ann N Y Acad Sci. 1966 Jun 14;132(2):860–869. doi: 10.1111/j.1749-6632.1966.tb43006.x. [DOI] [PubMed] [Google Scholar]
- Prokhorova I. I. O vsasyvaemosti kanamitsina pri ingaliatsii aérozolia. Antibiotiki. 1968 Apr;13(4):351–355. [PubMed] [Google Scholar]