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. 1970 Apr;19(4):613–617. doi: 10.1128/am.19.4.613-617.1970

Production of Rubratoxin B by Penicillium purpurogenum Stoll

Shinsaku Natori 1,2, Setsuko Sakaki 1,2, Hiroshi Kurata 1,2, Shun-Ichi Udagawa 1,2, Masakatsu Ichinoe 1,2, Mamoru Saito 1,2, Makoto Umeda 1,2, Kohichiro Ohtsubo 1,2
PMCID: PMC376749  PMID: 5418943

Abstract

Culture filtrates and chloroform extracts from Penicillium purpurogenum isolated from foodstuffs were subjected to preliminary survey for toxic effects on HeLa cells and mice. The toxic metabolite was isolated in a crystalline form from P. purpurogenum and was identified as rubratoxin B. Pathological findings observed in HeLa cells and mice treated with the metabolite are briefly described.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BAILEY W. S., GROTH A. H., Jr The relationship of hepatitis X of dogs and moldy corn poisoning of swine. J Am Vet Med Assoc. 1959 Jun 1;134(11):514–516. [PubMed] [Google Scholar]
  2. BALDWIN J. E., BARTON D. H., BLOOMER J. L., JACKMAN L. M., RODRIGUEZ-HAHN L., SUTHERLAND J. K. The constitutions of glauconic, glaucanic and byssochlamic acids. Experientia. 1962 Aug 15;18:345–352. doi: 10.1007/BF02172243. [DOI] [PubMed] [Google Scholar]
  3. BURNSIDE J. E., SIPPEL W. L., FORGACS J., CARLL W. T., ATWOOD M. B., DOLL E. R. A disease of swine and cattle caused by eating moldy corn. II. Experimental production with pure cultures of molds. Am J Vet Res. 1957 Oct;18(69):817–824. [PubMed] [Google Scholar]
  4. Carlton W. W., Tuite J., Mislivec P. Investigations of the toxic effects in mice of certain species of Penicillium. Toxicol Appl Pharmacol. 1968 Nov;13(3):372–387. doi: 10.1016/0041-008x(68)90113-0. [DOI] [PubMed] [Google Scholar]
  5. FORGACS J., KOCH H., CARLL W. T., WHITE-STEVENS R. H. Additional studies on the relationship of mycotoxicoses to the poultry hemorrhagic syndrome. Am J Vet Res. 1958 Jul;19(72):744–753. [PubMed] [Google Scholar]
  6. Hayes A. W., Wilson B. J. Bioproduction and purification of rubratoxin B. Appl Microbiol. 1968 Aug;16(8):1163–1167. doi: 10.1128/am.16.8.1163-1167.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Moss M. O., Robinson F. V., Wood A. B. Observations on the structure of the toxins from Penicillium rubrum. Chem Ind. 1967 May 6;18:755–757. [PubMed] [Google Scholar]
  8. Moss M. O., Robinson F. V., Wood A. B., Paisley H. M., Feeney J. Rubratoxin B, a proposed structure for a bis-anhydride rom Penicillium rubrum Stoll. Nature. 1968 Nov 23;220(5169):767–770. doi: 10.1038/220767a0. [DOI] [PubMed] [Google Scholar]
  9. Moss M. O., Robinson F. V., Wood A. B. Rubratoxin B, a toxic metabolite of Penicillium rubrum. Chem Ind. 1968 May 4;18:587–588. [PubMed] [Google Scholar]
  10. Moss M. O., Wood A. B., Robinson F. V. The structure of rubratoxin A, a toxic metabolite of Penicillium rebrum. Tetrahedron Lett. 1969 Jan;(5):367–370. doi: 10.1016/s0040-4039(01)87693-0. [DOI] [PubMed] [Google Scholar]
  11. TOPLIN I. A tissue culture cytotoxicity test for large-scale cancer chemotherapy screening. Cancer Res. 1959 Oct;19:959–965. [PubMed] [Google Scholar]
  12. Townsend R. J., Moss M. O., Peck H. M. Isolation and characterisation of hepatotoxins from Penicillum rubrum. J Pharm Pharmacol. 1966 Jul;18(7):471–473. doi: 10.1111/j.2042-7158.1966.tb07908.x. [DOI] [PubMed] [Google Scholar]
  13. WILSON B. J., WILSON C. H. Extraction and preliminary characterization of a hepatotoxic substance from cultures of Penicillium rubrum. J Bacteriol. 1962 Aug;84:283–290. doi: 10.1128/jb.84.2.283-290.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]

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