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. 1970 Jul;20(1):6–10. doi: 10.1128/am.20.1.6-10.1970

Australia Antigen in a Closed Adult Population Monitored for Serum Glutamic Oxalacetic Transaminase

K A Hok 1, R Nieman 1, J O Lackey 1, V J Cabasso 1
PMCID: PMC376856  PMID: 4989670

Abstract

A study of the presence of Australia antigen (Au/SH) was conducted over a period of 21 weeks among volunteer plasma donors living in a prison and being monitored for serum glutamic oxalacetic transaminase (SGOT). A good correlation was observed between the level of SGOT and presence of Au/SH, the latter being present in 33% of donors with SGOT values higher than 101 Karmen units and in 12% of those with SGOT values of 41 to 100 units. Furthermore, none of the 87 donors with all SGOT values below 40 was found positive for Au/SH. It should be noted, however, that single specimens only were tested from 72 of the 87 individuals. Au/SH was detected with equivalent efficiency by both agar gel precipitation and complement fixation procedures. Implications of these findings in the prognostication of hepatitis carrier state are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BANG N. U., RUEGSEGGER P., LEY A. B., LADUE J. S. Detection of hepatitis carriers by serum glutamic oxalacetic transaminase activity. J Am Med Assoc. 1959 Dec 26;171:2303–2306. doi: 10.1001/jama.1959.03010350025006. [DOI] [PubMed] [Google Scholar]
  2. Blumberg B. S., Gerstley B. J., Hungerford D. A., London W. T., Sutnick A. I. A serum antigen (Australia antigen) in Down's syndrome, leukemia, and hepatitis. Ann Intern Med. 1967 May;66(5):924–931. doi: 10.7326/0003-4819-66-5-924. [DOI] [PubMed] [Google Scholar]
  3. Blumberg B. S., Sutnick A. I., London W. T. Hepatitis and leukemia: their relation to Australia antigen. Bull N Y Acad Med. 1968 Dec;44(12):1566–1586. [PMC free article] [PubMed] [Google Scholar]
  4. Cossart Y., Taylor P. E., Vahrman J., Zuckerman A. J. Australia-SH antigen in hepatitis patients in London. Br Med J. 1969 Sep 27;3(5673):755–756. doi: 10.1136/bmj.3.5673.755. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Giles J. P., McCollum R. W., Berndtson L. W., Jr, Krugman S. Relation of Australia-SH antigen to the willowbrook MS-2 strain. N Engl J Med. 1969 Jul 17;281(3):119–122. doi: 10.1056/NEJM196907172810302. [DOI] [PubMed] [Google Scholar]
  6. Gocke D. J., Kavey N. B. Hepatitis antigen. Correlation with disease and infectivity of blood-donors. Lancet. 1969 May 31;1(7605):1055–1059. doi: 10.1016/s0140-6736(69)91701-2. [DOI] [PubMed] [Google Scholar]
  7. KARMEN A. A note on the spectrometric assay of glutamic-oxalacetic transaminase in human blood serum. J Clin Invest. 1955 Jan;34(1):131–133. [PubMed] [Google Scholar]
  8. London W. T., Di Figlia M., Sutnick A., Blumberg B. S. An epidemic of hepatitis in a chronic-hemodialysis unit. Australia antigen and differences in host response. N Engl J Med. 1969 Sep 11;281(11):571–578. doi: 10.1056/NEJM196909112811101. [DOI] [PubMed] [Google Scholar]
  9. London W. T., Sutnick A. I., Blumberg B. S. Australia antigen and acute viral hepatitis. Ann Intern Med. 1969 Jan;70(1):55–59. doi: 10.7326/0003-4819-70-1-55. [DOI] [PubMed] [Google Scholar]
  10. Okochi K., Murakami S. Observations on Australia antigen in Japanese. Vox Sang. 1968;15(5):374–385. doi: 10.1111/j.1423-0410.1968.tb04078.x. [DOI] [PubMed] [Google Scholar]
  11. Prince A. M. An antigen detected in the blood during the incubation period of serum hepatitis. Proc Natl Acad Sci U S A. 1968 Jul;60(3):814–821. doi: 10.1073/pnas.60.3.814. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Purcell R. H., Holland P. V., Walsh J. H., Wong D. C., Morrow A. G., Chanock R. M. A complement-fixation test for measuring Australia antigen and antibody. J Infect Dis. 1969 Sep;120(3):383–386. doi: 10.1093/infdis/120.3.383. [DOI] [PubMed] [Google Scholar]
  13. Shulman N. R., Barker L. F. Virus-like antigen, antibody, and antigen-antibody complexes in hepatitis measured by complement fixation. Science. 1969 Jul 18;165(3890):304–306. doi: 10.1126/science.165.3890.304. [DOI] [PubMed] [Google Scholar]
  14. Sutnick A. I., London W. T., Gerstley B. J., Cronlund M. M., Blumberg B. S. Anicteric hepatitis associated with Australia antigen. Occurrence in patients with Down's syndrome. JAMA. 1968 Sep 2;205(10):670–674. [PubMed] [Google Scholar]
  15. Turner G. C., White G. B. S.H. antigen in haemodialysis-associated hepatitis. Lancet. 1969 Jul 19;2(7612):121–124. [PubMed] [Google Scholar]
  16. Wright R., McCollum R. W., Klatskin G. Australia antigen in acute and chronic liver disease. Lancet. 1969 Jul 19;2(7612):117–121. doi: 10.1016/s0140-6736(69)92437-4. [DOI] [PubMed] [Google Scholar]

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