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. Author manuscript; available in PMC: 2013 Sep 11.
Published in final edited form as: Peptides. 2012 Sep 29;38(2):437–445. doi: 10.1016/j.peptides.2012.09.016

Table 3.

Structure, subcellular localization and distribution of intracellular RAS processing enzymes.

Enzyme Renin ACE Aminopetidase A Aminopetidase N
Structure 340 amino acid peptide Zinc- and
chloride-dependent
metallopeptidase(1277aa)		 Zinc-dependent
membrane-bound
aminopeptidase		 Zinc-dependent
membrane-bound
aminopeptidase
Subcellular localization Cytoplasm
Nucleus
Mitochondria		 Cytoplasm
Nucleus
Mitochondria
Endoplasmic reticulum		 Cytoplasm Cytoplasm
Cell type Adrenal glands, brain and
heart		 Mesangial, smooth muscle
and endothelial cells		 Brain
Kidney		 Brain
Kidney
Mesangial, smooth muscle
and endothelial cells
Function Mitochondrial
bioenergetics		 Peptide modification Unknown Unknown
Junctional conductance
Apoptosis calcium influx
Pathology Fluid homeostasis and BP
regulation		 Genetic hypertension Unknown Unknown

BP, blood pressure.