Skip to main content
Applied Microbiology logoLink to Applied Microbiology
. 1970 Nov;20(5):754–756. doi: 10.1128/am.20.5.754-756.1970

Effect of pH on the Activity of Erythromycin Against 500 Isolates of Gram-Negative Bacilli

Victor Lorian 1,2, L D Sabath 1,2
PMCID: PMC377039  PMID: 4991920

Abstract

Erythromycin was found to be a more effective inhibitor of gram-negative bacilli in alkaline medium than in neutral or acid medium. A definite effect was noted with all of 500 recent clinical isolates of Escherichia coli, Klebsiella-Enterobacter, Pseudomonas aeruginosa, and Proteus mirabilis studied, but it was most striking with E. coli. At pH 8.5 all strains, except for 14% of those of P. mirabilis, were inhibited by concentrations of erythromycin readily achieved in urine with common therapeutic doses.

Full text

PDF
754

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. GARROD L. P., WATERWORTH P. M. Behaviour in vitro of some new antistaphylococcal antibiotics. Br Med J. 1956 Jul 14;2(4984):61–65. doi: 10.1136/bmj.2.4984.61. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. REID D. B. W., CLARK E. M., RHODES A. J. Routine titrations of Lansing virus and antibody in mice: comparison of methods of estimating endpoints. Proc Soc Exp Biol Med. 1952 Oct;81(1):118–121. doi: 10.3181/00379727-81-19796. [DOI] [PubMed] [Google Scholar]
  3. Sabath L. D., Lorian V., Gerstein D., Loder P. B., Finland M. Enhancing effect on alkalinization of the medium on the activity of erythromycin against gram-negative bacteria. Appl Microbiol. 1968 Sep;16(9):1288–1292. doi: 10.1128/am.16.9.1288-1292.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. WILLIAMSON G. M., ZINNEMANN K. The susceptibility of coliform bacilli to erythromycin. Antibiot Chemother (Northfield) 1962 Mar;12:169–172. [PubMed] [Google Scholar]
  5. ZAGAR Z. Sensitivity of E. coli, Ps. aeruginosa and B. proteus to erythromycin in various pH culture media. Chemotherapia (Basel) 1963;6:82–89. [PubMed] [Google Scholar]
  6. Zinner S. H., Abath L. D., Casey J. I., Finland M. Erythromycin plus alkalinization in treatment of urinary infections. Antimicrob Agents Chemother (Bethesda) 1969;9:413–416. [PubMed] [Google Scholar]

Articles from Applied Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES