Abstract
This report describes the bioconversion of 19-hydroxy-androsta-4, 7-diene-3, 17-dione into equilin with Nocardia rubra. Through mutation and improvement of medium and of conditions, the bioconversion could be improved to yield 40% equilin for a substrate concentration of 1 g/liter. Aromatization of several other 19-hydroxy and 19-nor substrates of the androstene series is reported, and the influence of various substitutions of the substrate molecule on aromatization is discussed.
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Selected References
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- GUAL C., DORFMAN R. I., STITCH S. R. Microbiological transformations of steroids. Aromatization of ring A, cleavage of ring D and oxidation of the side chain in certain 19-nor steroids. Biochim Biophys Acta. 1961 May 13;49:387–389. doi: 10.1016/0006-3002(61)90139-1. [DOI] [PubMed] [Google Scholar]