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. 1971 Apr;21(4):606–610. doi: 10.1128/am.21.4.606-610.1971

Inactivation of Influenza and Other Viruses by a Mixture of Virucidal Compounds

J S Oxford 1,1, C W Potter 1, C McLaren 1, W Hardy 1
PMCID: PMC377239  PMID: 4102573

Abstract

A mixture of benzalkonium chloride, Triton X100, and citric acid (Resiguard F) had a marked virucidal effect on lipid-containing deoxyribonucleic and ribonucleic acid viruses, such as vaccinia virus, herpesvirus, and influenza virus. Adenoviruses and picornaviruses were more resistant to inactivation. Electron microscopy showed that influenza particles became aggregated in the presence of Resiguard F and that the outer fringe of hemagglutinin and neuraminidase spikes seen in control virus preparations became indistinct. The mixture had no detectable antiviral activity in mice infected with influenza AO/PR/8/34 virus, and this was attributed to the reduced virucidal effect of Resiguard F in the presence of serum proteins.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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