Table 3. Percentage of Trials Correct and Completed After Administration of Vehicle (‘V') and Doses (mg/kg) of SH-053-2′F-S-CH3 (n=4) and SH-053-2′F-R-CH3 (n=3) During DMTS Trials of 2-, 30-, and 300-s Delays.
| Dose |
%Trials correct (SEM) |
%Trials completed (SEM) |
||||
|---|---|---|---|---|---|---|
| 2-s | 30-s | 300-s | 2-s | 30-s | 300-s | |
| SH-053-2′F-S-CH3 (p.o.) | ||||||
| V | 93.1 (6.94) | 83.3 (2.41) | 52.8 (7.35) | 91.7 (8.33) | 91.7 (8.33) | 91.7 (8.33) |
| 3 | 91.7 (4.17) | 85.0 (2.50) | 41.7 (9.30) | 100 (0.00) | 87.5 (12.5) | 91.7 (4.17) |
| 5.6 | 93.8 (6.25) | 77.4 (12.4) | 66.7 (16.7) | 95.8 (4.17) | 91.7 (4.17) | 91.7 (8.33) |
| 10 | 95.8 (4.17) | 91.7 (8.33) | 36.3 (4.17) | 100 (0.00) | 95.8 (4.17) | 91.7 (4.17) |
| SH-053-2′F-R-CH3 (i.m.) | ||||||
| V | 89.2 (9.26) | 84.3 (6.16) | 54.2 (6.16) | 98.4 (0.90) | 99.2 (0.78) | 99.2 (0.78) |
| 0.03 | 84.4 (15.6) | 86.2 (10.1) | 56.3 (14.9) | 100 (0.00) | 96.9 (3.13) | 100 (0.00) |
| 0.3 | 84.4 (9.38) | 78.1 (10.7) | 53.6 (13.4) | 100 (0.00) | 100 (0.00) | 96.9 (3.13) |
| 1 | 78.1 (12.9) | 83.5 (6.49) | 64.3 (8.15) | 100 (0.00) | 96.9 (3.13) | 96.9 (3.13) |
| 1.8 | 87.5 (7.22) | 83.3 (16.7) | 60.7 (7.43) | 100 (0.00) | 100 (0.00) | 95.8 (4.17) |
Abbreviations: DMTS, delayed matching-to-sample; i.m., intramuscular; p.o., per os.