Table 2.

Treatment Outcomes of Acute Osteomyelitis.^*

Primary Outcome	Intravenous Therapy (1021) N (%)	Oral Therapy (948) N (%)	Propensity-score adjusted odds ratio (95% confidence interval) for those children treated with early transition to oral therapy
Treatment Failure within 6 months of diagnosis	54 (5)	38 (4)	0.77 (0.49, 1.22)
Chronic osteomyelitis	13 (1.3)	8 (0.8)	0.84 (0.33, 2.13)
Musculoskeletal surgery	18 (1.8)	15 (1.6)	0.80 (0.38, 1.70)
Complication of osteomyelitis**	11 (1.1)	6 (0.6)	0.75 (0.27, 2.07)
Acute osteomyelitis as sole readmission diagnosis	12 (1.2)	9 (0.9)	0.72 (0.25, 2.08)
Secondary Outcomes
Any re-hospitalization within 6 months of diagnosis	102 (10)	56 (5.9)	0.6 (0.38, 0.96)
Catheter-associated complication	35 (3)	0 (0)	---
Adverse effect of antimicrobials^	15 (1.5)	4 (0.4)	0.39 (0.14, 1.1)

^*Analysis used the complete cohort.

^**Includes synovitis, pyogenic arthritis, sacroilitis, disorders of bone and cartiliage NOS, and disc disorder

^{^} adverse drug reactions associated with antibiotics, C. difficile infection or agranulocytosis