Relationship Between Schizophrenia and Diabetes Mellitus: Consideration Based on Physiogenomics Data

Sir,

Diabetes mellitus is a common endocrine disorder that can be seen in any outpatient clinics around the world. The relationship between diabetes mellitus and schizophrenia is an interesting topic in psychological medicine. It is mentioned that the antipsychotics can have metabolic side effects that can result in diabetes mellitus.[1] Nevertheless, diabetes mellitus can be seen in many naïve schizophrenic patients without any antipsychotic medication.[2] The genetic underlying factors are presently focused as possible contributing factor to pathogenesis of diabetes in cases with schizorphrenia.[3] The autoimmunity process is usually raised as a supportive evidence to the hypothesis.[4] Nevertheless, there is still no proof for the case of diabetes mellitus type 2. Here, the authors have tried to study the relationship between schizophrenia and diabetes mellitus based on physiogenomics data. According to the previous physiogenomics study on diabetes mellitus type 2, two chromosomes, 12 and 18, have been mentioned as genetical ethologies of diabetes mellitus type 2.[5] In published literatures, there are some reports on chromosome 12 and 18 abnormalities in schizophrenia. However, when it is focused in depth in the reported problematic parts of the two chromosomes (chromosome 18 (BW_32H) and chromosome 12(GPD2)),[5] there is no report in schizophrenia. As a conclusion based on existed physiogenomical pathophysiology evidence, there is still no evidence on the genetic disorder that is on the common pathway for both diabetes mellitus type 2 and schizophrenia.