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. 1969 Feb;17(2):237–241. doi: 10.1128/am.17.2.237-241.1969

Microbiological Metabolism of Naphthyridines1

P B Hamilton a,2, D Rosi a, G P Peruzzotti a,3, E D Nielson a,4
PMCID: PMC377656  PMID: 5813297

Abstract

Penicillium adametzi and seven other species convert nalidixic acid, 1,4-dihydro-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid, to 1,4-dihydro-1-ethyl-7-hydroxymethyl-4-oxo-1,8-naphthyridine-3-carboxylic acid. Forty-seven other species from six orders of fungi seem to achieve the same conversion as judged by chromatographic and spectral evidence. Under special conditions, P. adametzi also produces a second metabolite which was identified as the corresponding 7-carboxylic acid. The metabolic attack on the ring substituent is identical with the pathway previously established with humans. No evidence was obtained for metabolic attack on the naphthyridine nucleus itself.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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