Skip to main content
NCBI home page
Applied Microbiology logoLink to Applied Microbiology
. 1969 Mar;17(3):394–398. doi: 10.1128/am.17.3.394-398.1969

Role of the Kidney in Staphylococcal Enterotoxemia

Edward V Staab a,1, John Niederhuber a,2, David A Rhoda a, Charles S Faulkner II a, William R Beisel a
PMCID: PMC377699  PMID: 4976324

Abstract

Highly purified staphylococcal enterotoxin B (SEB) is known to accumulate rapidly within the kidneys of experimental animals. The present study was performed to determine whether the predominant renal localization of SEB was of fundamental pathophysiologic importance in the development of lethal shock after the intravenous administration of this toxin to monkeys. Eight bilaterally nephrectomized Macaca mulatta given 10 μg of SEB per kg survived for an average time period less than half that of nephrectomized control animals (P < 0.001). Their survival time, however, was similar to that of control, sham-nephrectomized monkeys given an equal amount of SEB. Thus, no evidence was obtained to suggest that the kidney converted purified SEB to a more potent toxin. The glomerular filtration and proximal tubule cell accumulation of SEB possibly occurred as a nonspecific consequence of its molecular size, and such localization within the kidney might have served to reduce the quantity of SEB reaching some other site of toxic activity. Similar pathological and clinical findings were demonstrated in monkeys from both experimental and control groups; these could not be ascribed to SEB alone.

Full text

PDF
394

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beck L. V., Zaharko D. S., Roberts N., King C. On insulin I-131 metabolism in mice. Modifying effects of anti-insulin serum and of total insulin dosage. Diabetes. 1966 May;15(5):336–341. doi: 10.2337/diab.15.5.336. [DOI] [PubMed] [Google Scholar]
  2. Crawley G. J., Black J. N., Gray I., Blanchard J. W. Clinical chemistry of staphylococcal enterotoxin poisoning in monkeys. Appl Microbiol. 1966 May;14(3):445–450. doi: 10.1128/am.14.3.445-450.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Crawley G. J., Gray I., Leblang W. A., Blanchard J. W. Blood binding, distribution and excretion of staphylococcal enterotoxin in monkeys. J Infect Dis. 1966 Feb;116(1):48–56. doi: 10.1093/infdis/116.1.48. [DOI] [PubMed] [Google Scholar]
  4. Finegold M. J. Interstitial pulmonary edema. An electron microscopic study of the pathology of staphylococcal enterotoxemia in Rhesus monkeys. Lab Invest. 1967 Jun;16(6):912–924. doi: 10.21236/ad0811615. [DOI] [PubMed] [Google Scholar]
  5. Hodoval L. F., Morris E. L., Crawley G. J., Beisel W. R. Pathogenesis of lethal shock after intravenous staphylococcal enterotoxin B in monkeys. Appl Microbiol. 1968 Feb;16(2):187–192. doi: 10.21236/ad0666852. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. MIRSKY I. A. THE METABOLISM OF INSULIN. Diabetes. 1964 May-Jun;13:225–229. [PubMed] [Google Scholar]
  7. Morris E. L., Hodoval L. F., Beisel W. R. The unusual role of the kidney during intoxication of monkeys by intravenous staphylococcal enterotoxin B. J Infect Dis. 1967 Oct;117(4):273–284. doi: 10.1093/infdis/117.4.273. [DOI] [PubMed] [Google Scholar]
  8. NARAHARA H. T., EVERETT N. B., SIMMONS B. S., WILLIAMS R. H. Metabolism of insulin-I 131 and glucagon-I 131 in the kidney of the rat. Am J Physiol. 1958 Feb;192(2):227–231. doi: 10.1152/ajplegacy.1958.192.2.227. [DOI] [PubMed] [Google Scholar]
  9. Normann S. J., Jaeger R. F., Johnsey R. T. Pathology of experimental enterotoxemia. The in vivo localization of staphylococcal enterotoxin B. Lab Invest. 1969 Jan;20(1):17–25. [PubMed] [Google Scholar]
  10. Rapoport M. I., Hodoval L. F., Beisel W. R. Influence of thorotrast blockade and acute renal artery ligation on disappearance of staphylococcal enterotoxin B from blood. J Bacteriol. 1967 Mar;93(3):779–783. doi: 10.1128/jb.93.3.779-783.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. SKINNER D. G., HAYES M. A. EFFECT OF STAPHYLOCOCCAL TOXIN ON RENAL FUNCTION: IRREVERSIBLE SHOCK. Ann Surg. 1965 Aug;162:161–180. doi: 10.1097/00000658-196508000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Schantz E. J., Roessler W. G., Wagman J., Spero L., Dunnery D. A., Bergdoll M. S. Purification of staphylococcal enterotoxin B. Biochemistry. 1965 Jun;4(6):1011–1016. doi: 10.1021/bi00882a005. [DOI] [PubMed] [Google Scholar]
  13. Zaharko D. S., Beck L. V., Blankenbaker R. Role of the kidney in the disposal of radioiodinated and nonradioiodinated insulin in dogs. Diabetes. 1966 Sep;15(9):680–685. doi: 10.2337/diab.15.9.680. [DOI] [PubMed] [Google Scholar]

Articles from Applied Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES