Abstract
Suspensions of purified influenza virus, dried to a 1.4% content of residual moisture by sublimation of ice in vacuo, were sealed in a vacuum or under different gases of high purity. The stabilities of the several preparations were determined by an accelerated storage test. Based on the times predicted for the dried preparations stored at different temperatures to lose 1 log of infectivity titer, the order of stabilities in relation to sealing in vacuum or under different gases was as follows: helium > hydrogen > vacuum > argon > nitrogen > oxygen > carbon dioxide.
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- Benedict R. G., Sharpe E. S., Corman J., Meyers G. B., Baer E. F., Hall H. H., Jackson R. W. Preservation of Microorganisms by Freeze-drying: II. The Destructive Action of Oxygen. Additional Stabilizers for Serratia marcescens. Experiments with Other Microorganisms. Appl Microbiol. 1961 May;9(3):256–262. doi: 10.1128/am.9.3.256-262.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GREIFF D., RIGHTSEL W. A. AN ACCELERATED STORAGE TEST FOR PREDICTING THE STABILITY OF SUSPENSIONS OF MEASLES VIRUS DRIED BY SUBLIMATION IN VACUO. J Immunol. 1965 Mar;94:395–400. [PubMed] [Google Scholar]
- GREIFF D., RIGHTSEL W. A., SCHULER E. E. EFFECTS OF FREEZING, STORAGE AT LOW TEMPERATURES, AND DRYING BY SUBLIMATION IN VACUO ON THE ACTIVITIES OF MEASLES VIRUS. Nature. 1964 May 9;202:624–625. doi: 10.1038/202624a0. [DOI] [PubMed] [Google Scholar]
- Greiff D., Rightsel W. A. Stabilities of suspensions of viruses after freezing or drying by vacuum sublimation and storage. Cryobiology. 1967 May-Jun;3(6):432–444. doi: 10.1016/s0011-2240(67)80153-6. [DOI] [PubMed] [Google Scholar]
- Greiff D., Rightsel W. A. Stability of suspensions of influenza virus dried to different contents of residual moisture by sublimation in vacuo. Appl Microbiol. 1968 Jun;16(6):835–840. doi: 10.1128/am.16.6.835-840.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hirota S. Estimation of the shelf life of a drug in its solid state. II. A proposition for a new kinetical equation of gas-solid reactions for pharmaceutical solids. Chem Pharm Bull (Tokyo) 1968 Oct;16(10):1982–1993. doi: 10.1248/cpb.16.1982. [DOI] [PubMed] [Google Scholar]
- Hirota S., Osugi S., Hayashi T., Kaga S., Takeya Y. Estimation of the shelf life of a drug in its solid state. I. An application of Lacey's theory to a kinetic analysis of an air oxidation of ascorbic acid in its solid state. Chem Pharm Bull (Tokyo) 1968 Oct;16(10):1972–1981. doi: 10.1248/cpb.16.1972. [DOI] [PubMed] [Google Scholar]
- JOHANSEN G. The influence of oxygen on irreversible denaturation of beta-lacto-globulin. C R Trav Lab Carlsberg Chim. 1953;28(10-11):335–341. [PubMed] [Google Scholar]
- LION M. B., BERGMANN E. D. The effect of oxygen on freeze-dried Escherichia coli. J Gen Microbiol. 1961 Feb;24:191–200. doi: 10.1099/00221287-24-2-191. [DOI] [PubMed] [Google Scholar]
- LION M. B. QUANTITATIVE ASPECTS OF THE PROTECTION OF FREEZE-DRIED ESCHERICHIA COLI AGAINST THE TOXIC EFFECT OF OXYGEN. J Gen Microbiol. 1963 Sep;32:321–329. doi: 10.1099/00221287-32-3-321. [DOI] [PubMed] [Google Scholar]
- MAISTER H. G., PFEIFER V. F., BOGART W. M., HEGER E. N. Survival during storage of Serratia marcescens dried by continuous vacuum sublimation. Appl Microbiol. 1958 Nov;6(6):413–419. doi: 10.1128/am.6.6.413-419.1958. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Naylor H. B., Smith P. A. Factors Affecting the Viability of Serratia marcescens During Dehydration and Storage. J Bacteriol. 1946 Nov;52(5):565–573. doi: 10.1128/jb.52.5.565-573.1946. [DOI] [PMC free article] [PubMed] [Google Scholar]
- OBAYASHI Y., OTA S., ARAI S. Some factors affecting preservability of freeze-dried bacteria. J Hyg (Lond) 1961 Mar;59:77–91. doi: 10.1017/s0022172400038729. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rightsel W. A., Greiff D. Freezing and freeze-drying of viruses. Cryobiology. 1967 May-Jun;3(6):423–431. doi: 10.1016/s0011-2240(67)80152-4. [DOI] [PubMed] [Google Scholar]