Abstract
Various factors affecting the yields of luteoskyrin, a hepatotoxic mycotoxin, and related pigments in the liquid medium were studied. Maximal yields of luteoskyrin (0.13% by isolation) and of other pigments were attained in the late phase of the cultivation. The yield of the pigment was increased by supplying malt extract, malonic acid, glutamic acid, or asparagine. A useful material for preparation of 14C-labeled luteoskyrin was 2-14C-malonate.
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- KITAGAWA I., SHIBATA S. Metabolic products of fungi. X. The structure of rubroskyrin and its relation to the structure of luteoskyrin. Pharm Bull. 1956 Aug;4(4):309–313. doi: 10.1248/cpb1953.4.309. [DOI] [PubMed] [Google Scholar]
- Ohba Y., Fromageot P. Interactions entre pigments et acides nucléiques. 4. Complexes spécifiques et non spécifiques entre la lutéoskyrine, les ions magnésium et les acides nucléiques. Eur J Biochem. 1967 Apr;1(2):147–151. doi: 10.1111/j.1432-1033.1967.tb00056.x. [DOI] [PubMed] [Google Scholar]
- UENO I., UENO Y., TATSUNO T., URAGUCHI K. MITOCHONDRIAL RESPIRATORY IMPAIRMENT BY LUTEOSKYRIN, A HEPATOTOXIC PIGMENT OF PENICILLIUM ISLANDICUM SOPP. Jpn J Exp Med. 1964 Jun;34:135–152. [PubMed] [Google Scholar]
- UENO Y., UENO I., TATSUNO T., URAGUCHI K. LES EFFETS DE LA LUT'EOSKYRINE, SUBSTANCE TOXIQUE DU PENICILLIUM ISLANDICUM SOPP, SUR LE GONFLEMENT DES MITOCHONDRIES. Jpn J Exp Med. 1964 Aug;34:197–209. [PubMed] [Google Scholar]
- UMEDA M. CYTOTOXIC EFFECTS OF THE MYCOTOXINS OF PENICILLIUM ISLANDICUM SOPP, LUTEOSKYRIN AND CHLORINE-CONTAINING PEPTIDE ON CHANG'S LIVER CELLS AND HELA CELLS. Acta Pathol Jpn. 1964 Aug;14:373–394. doi: 10.1111/j.1440-1827.1964.tb00681.x. [DOI] [PubMed] [Google Scholar]
- Ueno Y., Saheki M. Inhibitory effects of luteoskyrin, a hepatotoxic pigment of Penicillium islandicum Sopp, and chemically related pigments on a protozoon, Tetrahymena pyriformis GL. Jpn J Exp Med. 1968 Jun;38(3):157–164. [PubMed] [Google Scholar]
- Ueno Y., Ueno I., Ito K., Tatsuno T. Impairments of RNA synthesis in Ehrlich ascites tumour by luteoskyrin, a hepatotoxic pigment of Penicillium islandicum Sopp. Experientia. 1967 Dec 15;23(12):1001–1002. doi: 10.1007/BF02136409. [DOI] [PubMed] [Google Scholar]
- Ueno Y., Ueno I., Mizumoto K., Tatsuno T. The binding of luteoskyrin, a hepatotoxic pigment of Penicillium islandicum sopp, to deoxyribonucleohistone. J Biochem. 1968 Mar;63(3):395–397. [PubMed] [Google Scholar]
- Ueno Y., Ueno I., Mizumoto K. The mode of binding of luteoskyrin, a hepatotoxic pigment of Penicillium islandicum Sopp, to deoxyribonucleic acid. Jpn J Exp Med. 1968 Feb;38(1):47–64. [PubMed] [Google Scholar]