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. 1969 Sep;18(3):474–478. doi: 10.1128/am.18.3.474-478.1969

Effectiveness of Therapy with a Multistranded Synthetic Polynucleotide Complex Against a Murine Sarcoma Virus

John W Pearson 1, Willie Turner 1, Paul S Ebert 1, M A Chirigos 1
PMCID: PMC378007  PMID: 5373679

Abstract

A known interferon stimulator, polyriboinosinic acid:polyribocytidylic acid (rI:rC), was shown to have a protective effect against a highly tumorigenic variant of the murine sarcoma virus (Moloney) designated as (MSV-PV). Mice treated intraperitoneally with different regimens of rI:rC survived significantly longer than untreated controls. The treatment was effective whether the infection with MSV-PV was intraperitoneal or intracerebral. The antiviral effectiveness of rI:rC was demonstrated by marked reduction of viral replication. The kinetic study of interferon induction by rI:rC showed a peak titer of interferon occurring at 18 hr after injection, followed by a rapid decrease in titer by 24 hr.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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