Levosimendan is a well established drug used nowadays routinely for the treatment of heart failure both in cardiology [1] as well as in cardiac surgery [2] despite the relatively high costs of administration [3] and the few, one must admit, adverse effects [4]. The review article by Angadi et al. [5] deals with the interesting subject of levosimendan remedy in paediatric heart surgical patients reporting overall good results, although larger studies are considered necessary to confirm the efficacy and safety of the drug in this fragile category of patients. However, the article allows all involved surgeons and physicians to consider the administration of the drug more openly and without reservations, at least in those cases where other pharmaceutical agents cannot bring the solution.
Conflict of interest: none declared
References
- 1.Pathac A, Lebrin M, Vaccaro A, Senard JM, Despas F. Pharmacology of levosimendan: inotropic, vasodilatory and cardioprotective effects. J Clin Pharm Ther 2013; doi:10.1111/jcpt.12067 [DOI] [PubMed] [Google Scholar]
- 2.Tagarakis GI, Tsilimingas NB. Levosimendan for heart-operated patients: what is the state of the art? Recent Pat Cardiovasc Drug Discov 2009;4:22–4 [DOI] [PubMed] [Google Scholar]
- 3.De Lissovoy G, Fraeman K, Salon J, Chay Woodward T, Sterz R. The costs of treating acute heart failure: an economic analysis of the SURVIVE trial. J Med Econ 2008;11:415–29 [DOI] [PubMed] [Google Scholar]
- 4.Tagarakis GI, Baddour AJ, Tsilimingas NB. Can pulmonary artery hypertension be attributed to levosimendan? A problematic based on a patient's case. J Cardiovasc Med (Hagerstown) 2010;11:552–3 [DOI] [PubMed] [Google Scholar]
- 5.Angadi U, Wetsrope C, Chowdry MF. Is levosimendan effective in paediatric heart failure and post-cardiac surgeries? Interact CardioVasc Thorac Surg 2013;17:710–15 [DOI] [PMC free article] [PubMed] [Google Scholar]
