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. 1969 Dec;18(6):1031–1035. doi: 10.1128/am.18.6.1031-1035.1969

Microbial Production of Xylitol from Glucose1

Hiroshi Onishi a, Toshiyuki Suzuki a
PMCID: PMC378187  PMID: 5370655

Abstract

A microbiological method is described for the production of xylitol, which is used as a sugar substitute for diabetics. A sequential fermentation process yielded 9.0 g of xylitol from 77.5 g of glucose via D-arabitol and D-xylulose. Candida guilliermondii var. soya (ATCC 20216) consumed 5.1 g of D-xylulose and produced 2.8 g of xylitol per 100 ml. Pentitol production from D-xylulose by yeasts was divided into three types: I, yeast-produced xylitol; II, yeast-produced D-arabitol; and III, yeast-produced xylitol and D-arabitol. D-Xylulose, but not glucose, was dissimilated to xylitol by yeasts under aerobic conditions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABELES R. H., DORFMAN A., ROSEMAN S. Behavior of carbohydrates toward strongly basic ion-exchange resins. Arch Biochem Biophys. 1952 Mar;36(1):232–233. doi: 10.1016/0003-9861(52)90394-9. [DOI] [PubMed] [Google Scholar]
  2. BLAKLEY E. R., SPENCER J. F. Studies on the formation of D-arabitol by osmophilic yeasts. Can J Biochem Physiol. 1962 Dec;40:1737–1748. [PubMed] [Google Scholar]
  3. DISCHE Z., BORENFREUND E. A new spectrophotometric method for the detection and determination of keto sugars and trioses. J Biol Chem. 1951 Oct;192(2):583–587. [PubMed] [Google Scholar]
  4. INGRAM J. M., WOOD W. A. ENZYMATIC BASIS FOR D-ARBITOL PRODUCTION BY SACCHAROMYCES ROUXII. J Bacteriol. 1965 May;89:1186–1194. doi: 10.1128/jb.89.5.1186-1194.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. LANG K. DIE ERNAEHRUNGSPHYSIOLOGISCHEN EIGENSCHAFTEN VON XYLIT. Int Z Vitaminforsch. 1964;34:117–122. [PubMed] [Google Scholar]
  6. MELLINGHOFF C. H. [The usefulness of xylitol as a sugar substitute in diabetics]. Klin Wochenschr. 1961 Apr 15;39:447–447. doi: 10.1007/BF01481411. [DOI] [PubMed] [Google Scholar]
  7. MOSES V., FERRIER R. J. The biochemical preparation of D-xylulose and L-ribulose. Details of the action of Acetobacter suboxydans on D-arabitol, ribitol and other polyhydroxy compounds. Biochem J. 1962 Apr;83:8–14. doi: 10.1042/bj0830008. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Nickerson W. J., Brown R. G. Uses and products of yeasts and yeastlike fungi. Adv Appl Microbiol. 1965;7:225–272. doi: 10.1016/s0065-2164(08)70388-5. [DOI] [PubMed] [Google Scholar]
  9. Onishi H., Perry M. B. The production of meso-glycero-ido-heptitol and D-glycero-D-ido-heptitol by Pichia miso. Can J Microbiol. 1965 Dec;11(6):929–934. doi: 10.1139/m65-123. [DOI] [PubMed] [Google Scholar]
  10. Onishi H., Suzuki T. Formation of dulcitol in aerobic dissimilation of D-galactose by yeasts. J Bacteriol. 1968 May;95(5):1745–1749. doi: 10.1128/jb.95.5.1745-1749.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Onishi H., Suzuki T. Production of D-mannitol and glycerol by yeasts. Appl Microbiol. 1968 Dec;16(12):1847–1852. doi: 10.1128/am.16.12.1847-1852.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. SPENCER J. F., SALLANS H. R. Production of polyhydric alcohols by osmophilic yeasts. Can J Microbiol. 1956 Apr;2(2):72–79. doi: 10.1139/m56-011. [DOI] [PubMed] [Google Scholar]
  13. Spencer J. F. Production of polyhydric alcohols by yeasts. Prog Ind Microbiol. 1968;7:1–42. [PubMed] [Google Scholar]

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