. Author manuscript; available in PMC: 2014 Sep 1.

Published in final edited form as: Biofactors. 2013 Jun 27;39(5):10.1002/biof.1113. doi: 10.1002/biof.1113

Table 8.

Effects of oral administration of IFNT on concentrations of glutathione, tetrahydrobiopterin, glycogen, and triacylglycerols in tissues of ZDF rats

Tissue	Oral IFNT dose (μg/kg BW/day)
Tissue	0	4	8
	Reduced glutathione (GSH, μmol/g wet tissue)
Liver	4.10 ± 0.14^b	4.26 ± 0.11^b	4.84 ± 0.13^a
Gastrocnemius muscle	1.30 ± 0.06^b	1.35 ± 0.04^b	1.63 ± 0.05^a
Abdominal adipose tissue	0.46 ± 0.02^b	0.47 ± 0.01^b	0.55 ± 0.02^a
	Oxidized glutathione (GSSG, nmol/g tissue)
Liver	509 ± 22^a	443 ± 16^b	387 ± 14^c
Gastrocnemius muscle	227 ± 6^a	214 ± 10^a	184 ± 5^b
Abdominal adipose tissue	119 ± 6^a	112 ± 5^a	94 ± 4^b
	Ratio of GSH to GSSG (μmol/μmol)
Liver	0.125 ± 0.006^a	0.104 ± 0.005^b	0.080 ± 0.004^c
Gastrocnemius muscle	0.177 ± 0.010^a	0.158 ± 0.006^a	0.114 ± 0.005^b
Abdominal adipose tissue	0.265 ± 0.017^a	0.241 ± 0.014^a	0.173 ± 0.009^b
	Tetrahydrobiopterin (nmol/g wet tissue)
Liver	2.25 ± 0.07^c	2.59 ± 0.09^b	3.04 ± 0.12^a
Gastrocnemius muscle	0.118 ± 0.005^b	0.125 ± 0.006^b	0.159 ± 0.008^a
Abdominal adipose tissue	0.295 ± 0.022^b	0.304 ± 0.015^b	0.374 ± 0.020^a
	Glycogen (mg/g wet tissue)
Liver	49.5 ± 1.2^a	43.7 ± 1.0^b	37.0 ± 0.8^c
Gastrocnemius muscle	17.0 ± 0.5^a	16.1 ± 0.5^a	14.0 ± 0.3^b
Abdominal adipose tissue	1.82 ± 0.08^a	1.69 ± 0.07^a	1.42 ± 0.05^b
	Lipids (mg/g wet tissue for liver and muscle; or % for WAT)
Liver	54.7 ± 1.4^a	48.3 ± 1.1^b	40.5 ± 0.9^c
Gastrocnemius muscle	23.2 ± 1.2^a	21.9 ± 0.9^a	17.6 ± 0.7^b
Abdominal adipose tissue	81.7 ± 0.7	81.2 ± 0.6	81.5 ± 0.6

Values are the means ± SEM, n = 6 per treatment.

^a-c

Values within a row with different superscript letters differ (P < 0.05), as analyzed by one-way ANOVA. WAT, white adipose tissue.