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. 2013 Jul 15;4(8):1230–1240. doi: 10.18632/oncotarget.1145

Figure 2. CD138- cells colonized and produced tumors in the liver and bone marrow of mice.

Figure 2

NOG mice injected with CD138- or CD138+ cells or PBS into their tail vein and observed for 14-16 weeks were sacrificed once they developed symptoms of myeloma or at the end of the observation period; liver and bone marrow were collected from them. (A) Liver tissues harvested from mice injected with (i) CD138−, (ii) CD138+ cells but not (iii) PBS developed tumor nodules (arrows). However tumor frequency was less and tumor size was smaller in those injected with CD138+ cells. (B) Human CD138+ cells were detectable by immnohistochemistry in the liver tumor of mice injected with (i) CD138− and (ii) CD138+ cells. CD138+ cells are not detectable in liver tissue of mice injected with (iii) PBS. (C) Immuno-detection of human CD138+ cells (arrows) in the bone marrow of mice injected with (i) CD138−, (ii) CD138+ but not those injected with (iii) PBS. Original magnification (Olympus CK 40 microscope): X100 for panels B and C.