Skip to main content
. 2013 Jul 26;4(8):1317–1328. doi: 10.18632/oncotarget.1170

Figure 2. Weak prognostic power of “Mouse Social Defeat Signature” compared with 1000 random signatures in HER2+ breast cancer patients.

Figure 2

Of the 163 genes in the Mouse Social Defeat (MSD) signature, 148 were found on GPL570 and 127 on GPL96 platforms. Analysis was performed with 116 HER2+ patients from 2 GPL570 cohorts (GSEs 16446 and 20685 with Overall Survival (OS) data) and 145 HER2+ patients from 6 GPL96 cohorts (GSEs 2034, 2603, 5327, 6532, 11121, and 25066 with Metastasis-Free Survival (MFS) data). The MFS cohorts contain 53 HER2+:ER− patients, sufficient for independent analysis. A set of 1000 random signatures with the same number of genes was generated from atmosphere background noise (random.org) for the OS analysis, and another set for MFS. We then used SSM algorithm (assuming all genes are up-regulated) to differentiate samples in OS and MFS cohorts. The signatures were ranked by HR and compared with Mouse Social Defeat Signature (red boxes). The % signatures with significant HR > 2.0 are listed at the bottom. Comparing to 1000 sets of random signatures, Mouse Social Defeat Signature ranked 124 for HER2+ MFS samples, 363 for HER2+ OS samples, and 368 for HER2+:ER− MFS samples.