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. 2013 Aug 16;122(14):2346–2357. doi: 10.1182/blood-2013-03-487801

Figure 1.

Figure 1

Effect of ovx on HSPC expansion in T cell–replete and T cell–deficient mice. (A-C) Effects of ovx on the relative frequency of LSK cells in WT mice, TCRβKO mice, and TCRβKO mice previously subjected to adoptive transfer of T cells. Lin− cells were gated and analyzed for Sca-1 and c-Kit expression using isotype control settings. (Left) Representative flow cytometric dot plots from 1 mouse per group. The black box delineates c-Kit+ Sca-1+ cells. Parent population is Lin−. Data are expressed as percentage of total Lin− cells. (Right) Mean ± standard error of the mean (SEM) for each group. Data are expressed as percentage of total BM mononucleated cells (BMMCs). (D) Effect of ovx on the number of BM B cells, monocytes, erythroid cells, and granulocytes. n = 10 mice per group. *P < .05 and **P < .01 compared with the corresponding sham-operated group.