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. 2013 Oct 8;21(10):1743–1756. doi: 10.1016/j.str.2013.08.004

Figure 6.

Figure 6

Homologs of the FUN-EGF1 and EGF2-EGF3 Domain Pairs

(A) Sequence alignment of homologs of the FUN-EGF1 domain pair in other proteins (LTBP-1L, LTBP-2, and VWCE). The LTBPs lack the four-residue sequence preceding the C-C motif.

(B–E) Packing residues in EGF-EGF domain pairs, also showing the interdomain twist and tilt angles. The backbone rmsd from the fibrillin-1 EGF2-EGF3 pair, calculated using the Superpose server (Maiti et al., 2004), is given for the three homologs.

(B) Fibrillin-1 EGF2-EGF3.

(C) Human hedgehog interacting protein (HHIP) EGF1-EGF2 (PDB ID 3H0B).

(D) Wnt inhibitory factor-1 (WIF-1) EGF2-EGF3 (PDB ID 1IVO).

(E) Human Jagged-1 EGF1-EGF2 (PDB ID 2V2J).

(F) Sequence alignment of fibrillin-1, HHIP, WIF-1, and Jagged EGF-EGF domain pairs. Packing residues are colored red and indicated above the sequences. Additional packing residues in Jagged-1 are highlighted in blue.