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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Neuropharmacology. 2013 Mar 4;78:45–54. doi: 10.1016/j.neuropharm.2013.02.016

Figure 3. Visual deprivation induced unimodal and cross-modal homeostatic synaptic plasticity.

Figure 3

Unimodal changes in V1 and cross-modal changes in S1 require distinct sensory requirements. At the cellular level, unimodal and cross-modal changes occur in opposite directions at excitatory synapses and follows the rules of multiplicative synaptic scaling. The underlying molecular mechanisms are conserved, such that scaling up of synapses in both cortical areas involve synaptic expression of CP-AMPARs, and scaling down depend on immediate early gene Arc and remove of synaptic AMPARs.