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. 2013 Oct 10;7:211–221. doi: 10.2147/BTT.S25095

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© 2013 Franz. This work is published by Dove Medical Press Ltd, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Ltd, provided the work is properly attributed.

PMC Copyright notice

The mammalian target of rapamycin signaling pathway.

Note: Franz DN et al. Journal of Child Neurology. 28(5):602–607, Copyright © 2013 by Sage. Reprinted by Permission of SAGE Publications.²²

Abbreviations: 4E-BP1, 4E binding protein 1; Abl, Abelson kinase; Akt, protein kinase B; eIF-4E, eukaryotic initiation factor 4E; IGF-1R, insulin-like growth factor-1 receptor; PI3K, phosphoinositide 3-kinase; Pten, phosphatase and tensin homolog; RAS, rat sarcoma; S6K1, 40 S ribosomal S6 kinase; TSC1, tuberous sclerosis complex 1; TSC2, tuberous sclerosis complex 2.